Effects of pre-existing anti-adenovirus antibodies on transgene expression levels and therapeutic efficacies of arming oncolytic adenovirus

Oncolytic adenoviruses (OAds), most of which are based on species C human adenovirus serotype 5 (Ad5) (OAd5), have recently received much attention as potential anticancer agents. High seroprevalence of anti-Ad5 neutralizing antibodies is a major hurdle for Ad5-based gene therapy. However, the impac...

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Detalles Bibliográficos
Autores principales: Ono, Ryosuke, Nishimae, Fumitaka, Wakida, Takuro, Sakurai, Fuminori, Mizuguchi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747716/
https://www.ncbi.nlm.nih.gov/pubmed/36513733
http://dx.doi.org/10.1038/s41598-022-26030-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747716/
https://www.ncbi.nlm.nih.gov/pubmed/36513733
http://dx.doi.org/10.1038/s41598-022-26030-3

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