“Liver–gut” axis: A target of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) occurs when fat accumulates in the liver even without excessive alcohol intake. Among the current therapeutic approaches for NAFLD, lifestyle modification with dietary changes and regular exercise is the mainstay treatment. With the rise of intestinal microe...

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Autores principales: Guo, Kangxiao, Xu, Sisheng, Zeng, Zhaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747758/
https://www.ncbi.nlm.nih.gov/pubmed/36531498
http://dx.doi.org/10.3389/fendo.2022.1050709
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author Guo, Kangxiao
Xu, Sisheng
Zeng, Zhaofeng
author_facet Guo, Kangxiao
Xu, Sisheng
Zeng, Zhaofeng
author_sort Guo, Kangxiao
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) occurs when fat accumulates in the liver even without excessive alcohol intake. Among the current therapeutic approaches for NAFLD, lifestyle modification with dietary changes and regular exercise is the mainstay treatment. With the rise of intestinal microecology, regulation of the “liver–gut” axis can be an effective treatment for NAFLD. This review aimed to assess the modulation of the liver–gut microbiota axis with traditional Chinese medicine (TCM) as a therapeutic approach to NAFLD and further explored its application in the newly discovered therapeutic avenues beyond NAFLD treatment.
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spelling pubmed-97477582022-12-15 “Liver–gut” axis: A target of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease Guo, Kangxiao Xu, Sisheng Zeng, Zhaofeng Front Endocrinol (Lausanne) Endocrinology Non-alcoholic fatty liver disease (NAFLD) occurs when fat accumulates in the liver even without excessive alcohol intake. Among the current therapeutic approaches for NAFLD, lifestyle modification with dietary changes and regular exercise is the mainstay treatment. With the rise of intestinal microecology, regulation of the “liver–gut” axis can be an effective treatment for NAFLD. This review aimed to assess the modulation of the liver–gut microbiota axis with traditional Chinese medicine (TCM) as a therapeutic approach to NAFLD and further explored its application in the newly discovered therapeutic avenues beyond NAFLD treatment. Frontiers Media S.A. 2022-11-30 /pmc/articles/PMC9747758/ /pubmed/36531498 http://dx.doi.org/10.3389/fendo.2022.1050709 Text en Copyright © 2022 Guo, Xu and Zeng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Guo, Kangxiao
Xu, Sisheng
Zeng, Zhaofeng
“Liver–gut” axis: A target of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease
title “Liver–gut” axis: A target of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease
title_full “Liver–gut” axis: A target of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease
title_fullStr “Liver–gut” axis: A target of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease
title_full_unstemmed “Liver–gut” axis: A target of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease
title_short “Liver–gut” axis: A target of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease
title_sort “liver–gut” axis: a target of traditional chinese medicine for the treatment of non-alcoholic fatty liver disease
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747758/
https://www.ncbi.nlm.nih.gov/pubmed/36531498
http://dx.doi.org/10.3389/fendo.2022.1050709
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AT xusisheng livergutaxisatargetoftraditionalchinesemedicineforthetreatmentofnonalcoholicfattyliverdisease
AT zengzhaofeng livergutaxisatargetoftraditionalchinesemedicineforthetreatmentofnonalcoholicfattyliverdisease

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