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Human blood vessel microbiota in healthy adults based on common femoral arteries of brain-dead multi-organ donors
Discovery of human microbiota is fundamentally changing our perceptions of certain diseases and their treatments. However little is known about the human blood vessel microbiota, it may have important effects on vascular pathological lesions and vascular homograft failure. In our prospective survey...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747773/ https://www.ncbi.nlm.nih.gov/pubmed/36530429 http://dx.doi.org/10.3389/fcimb.2022.1056319 |
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author | Hidi, László Kovács, Gergely Imre Szabó, Dóra Makra, Nóra Pénzes, Kinga Juhász, János Sótonyi, Péter Ostorházi, Eszter |
author_facet | Hidi, László Kovács, Gergely Imre Szabó, Dóra Makra, Nóra Pénzes, Kinga Juhász, János Sótonyi, Péter Ostorházi, Eszter |
author_sort | Hidi, László |
collection | PubMed |
description | Discovery of human microbiota is fundamentally changing our perceptions of certain diseases and their treatments. However little is known about the human blood vessel microbiota, it may have important effects on vascular pathological lesions and vascular homograft failure. In our prospective survey study fourteen femoral arteries, harvested from donors in multi-organ donations, were examined using the V3-V4 region 16S rRNA sequencing method. The most abundant phyla in the human vascular microbiota were Proteobacteria, Firmicutes and Actinobacteria. At the genus level, the most abundant taxa were Staphylococcus, Corynebacterium, Pseudomonas, Bacillus, Acinetobacter and Propionibacterium. Of the bacterial taxa that have an indirect effect on the development of atherosclerosis, we found Porphyromonas gingivalis, Prevotella nigrescens and Enterobacteriaceae spp. with different abundances in our samples. Of the bacteria that are more common in the intestinal flora of healthy than of atherosclerosis patients, Roseburia and Ruminococcus occurred in the majority of samples. The human arterial wall has a unique microbiota that is significantly different in composition from that of other areas of the body. Our present study provides a basis for ensuing research that investigates the direct role of the microbiota in vascular wall abnormalities and the success of vascular allograft transplantations. |
format | Online Article Text |
id | pubmed-9747773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97477732022-12-15 Human blood vessel microbiota in healthy adults based on common femoral arteries of brain-dead multi-organ donors Hidi, László Kovács, Gergely Imre Szabó, Dóra Makra, Nóra Pénzes, Kinga Juhász, János Sótonyi, Péter Ostorházi, Eszter Front Cell Infect Microbiol Cellular and Infection Microbiology Discovery of human microbiota is fundamentally changing our perceptions of certain diseases and their treatments. However little is known about the human blood vessel microbiota, it may have important effects on vascular pathological lesions and vascular homograft failure. In our prospective survey study fourteen femoral arteries, harvested from donors in multi-organ donations, were examined using the V3-V4 region 16S rRNA sequencing method. The most abundant phyla in the human vascular microbiota were Proteobacteria, Firmicutes and Actinobacteria. At the genus level, the most abundant taxa were Staphylococcus, Corynebacterium, Pseudomonas, Bacillus, Acinetobacter and Propionibacterium. Of the bacterial taxa that have an indirect effect on the development of atherosclerosis, we found Porphyromonas gingivalis, Prevotella nigrescens and Enterobacteriaceae spp. with different abundances in our samples. Of the bacteria that are more common in the intestinal flora of healthy than of atherosclerosis patients, Roseburia and Ruminococcus occurred in the majority of samples. The human arterial wall has a unique microbiota that is significantly different in composition from that of other areas of the body. Our present study provides a basis for ensuing research that investigates the direct role of the microbiota in vascular wall abnormalities and the success of vascular allograft transplantations. Frontiers Media S.A. 2022-11-30 /pmc/articles/PMC9747773/ /pubmed/36530429 http://dx.doi.org/10.3389/fcimb.2022.1056319 Text en Copyright © 2022 Hidi, Kovács, Szabó, Makra, Pénzes, Juhász, Sótonyi and Ostorházi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Hidi, László Kovács, Gergely Imre Szabó, Dóra Makra, Nóra Pénzes, Kinga Juhász, János Sótonyi, Péter Ostorházi, Eszter Human blood vessel microbiota in healthy adults based on common femoral arteries of brain-dead multi-organ donors |
title | Human blood vessel microbiota in healthy adults based on common femoral arteries of brain-dead multi-organ donors |
title_full | Human blood vessel microbiota in healthy adults based on common femoral arteries of brain-dead multi-organ donors |
title_fullStr | Human blood vessel microbiota in healthy adults based on common femoral arteries of brain-dead multi-organ donors |
title_full_unstemmed | Human blood vessel microbiota in healthy adults based on common femoral arteries of brain-dead multi-organ donors |
title_short | Human blood vessel microbiota in healthy adults based on common femoral arteries of brain-dead multi-organ donors |
title_sort | human blood vessel microbiota in healthy adults based on common femoral arteries of brain-dead multi-organ donors |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747773/ https://www.ncbi.nlm.nih.gov/pubmed/36530429 http://dx.doi.org/10.3389/fcimb.2022.1056319 |
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