Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation

Stimulator of interferon gene (STING) is increasingly exploited for the potential in cancer immunotherapy, yet its mechanism of activation remains not fully understood. Herein, we designed a novel STING agonist, designated as HB3089 that exhibits robust and durable anti-tumor activity in tumor model...

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Detalles Bibliográficos
Autores principales: Xie, Zuoquan, Wang, Zhen, Fan, Fengying, Zhou, Jinpei, Hu, Zhaoxue, Wang, Qingxia, Wang, Xiyuan, Zeng, Qingzhong, Zhang, Yan, Qiu, Jiaxuan, Zhou, Xiaoqian, Xu, Hui, Bai, Hudagula, Zhan, Zhengsheng, Ding, Jian, Zhang, Huibin, Duan, Wenhu, Yu, Xuekui, Geng, Meiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747920/
https://www.ncbi.nlm.nih.gov/pubmed/36513640
http://dx.doi.org/10.1038/s41421-022-00481-4

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