Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors

G Protein-coupled receptors (GPCRs) are the most frequently exploited drug target family, moreover they are often found mutated in cancer. Here we used a dataset of mutations found in patient samples derived from the Genomic Data Commons and compared it to the natural human variance as exemplified b...

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Detalles Bibliográficos
Autores principales: Bongers, B. J., Gorostiola González, M., Wang, X., van Vlijmen, H. W. T., Jespers, W., Gutiérrez-de-Terán, H., Ye, K., IJzerman, A. P., Heitman, L. H., van Westen, G. J. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747925/
https://www.ncbi.nlm.nih.gov/pubmed/36513718
http://dx.doi.org/10.1038/s41598-022-25323-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747925/
https://www.ncbi.nlm.nih.gov/pubmed/36513718
http://dx.doi.org/10.1038/s41598-022-25323-x

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