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Identifying the neural marker of chronic sciatica using multimodal neuroimaging and machine learning analyses
INTRODUCTION: Sciatica is a pain disorder often caused by the herniated disk compressing the lumbosacral nerve roots. Neuroimaging studies have identified functional abnormalities in patients with chronic sciatica (CS). However, few studies have investigated the neural marker of CS using brain struc...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748090/ https://www.ncbi.nlm.nih.gov/pubmed/36532276 http://dx.doi.org/10.3389/fnins.2022.1036487 |
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author | Wei, Xiaoya Wang, Liqiong Yu, Fangting Lee, Chihkai Liu, Ni Ren, Mengmeng Tu, Jianfeng Zhou, Hang Shi, Guangxia Wang, Xu Liu, Cun-Zhi |
author_facet | Wei, Xiaoya Wang, Liqiong Yu, Fangting Lee, Chihkai Liu, Ni Ren, Mengmeng Tu, Jianfeng Zhou, Hang Shi, Guangxia Wang, Xu Liu, Cun-Zhi |
author_sort | Wei, Xiaoya |
collection | PubMed |
description | INTRODUCTION: Sciatica is a pain disorder often caused by the herniated disk compressing the lumbosacral nerve roots. Neuroimaging studies have identified functional abnormalities in patients with chronic sciatica (CS). However, few studies have investigated the neural marker of CS using brain structure and the classification value of multidimensional neuroimaging features in CS patients is unclear. METHODS: Here, structural and resting-state functional magnetic resonance imaging (fMRI) was acquired for 34 CS patients and 36 matched healthy controls (HCs). We analyzed cortical surface area, cortical thickness, amplitude of low-frequency fluctuation (ALFF), regional homogeneity (REHO), between-regions functional connectivity (FC), and assessed the correlation between neuroimaging measures and clinical scores. Finally, the multimodal neuroimaging features were used to differentiate the CS patients and HC individuals by support vector machine (SVM) algorithm. RESULTS: Compared to HC, CS patients had a larger cortical surface area in the right banks of the superior temporal sulcus and rostral anterior cingulate; higher ALFF value in the left inferior frontal gyrus; enhanced FCs between somatomotor and ventral attention network. Three FCs values were associated with clinical pain scores. Furthermore, the three multimodal neuroimaging features with significant differences between groups and the SVM algorithm could classify CS patients and HC with an accuracy of 90.00%. DISCUSSION: Together, our findings revealed extensive reorganization of local functional properties, surface area, and network metrics in CS patients. The success of patient identification highlights the potential of using artificial intelligence and multimodal neuroimaging markers in chronic pain research. |
format | Online Article Text |
id | pubmed-9748090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97480902022-12-15 Identifying the neural marker of chronic sciatica using multimodal neuroimaging and machine learning analyses Wei, Xiaoya Wang, Liqiong Yu, Fangting Lee, Chihkai Liu, Ni Ren, Mengmeng Tu, Jianfeng Zhou, Hang Shi, Guangxia Wang, Xu Liu, Cun-Zhi Front Neurosci Neuroscience INTRODUCTION: Sciatica is a pain disorder often caused by the herniated disk compressing the lumbosacral nerve roots. Neuroimaging studies have identified functional abnormalities in patients with chronic sciatica (CS). However, few studies have investigated the neural marker of CS using brain structure and the classification value of multidimensional neuroimaging features in CS patients is unclear. METHODS: Here, structural and resting-state functional magnetic resonance imaging (fMRI) was acquired for 34 CS patients and 36 matched healthy controls (HCs). We analyzed cortical surface area, cortical thickness, amplitude of low-frequency fluctuation (ALFF), regional homogeneity (REHO), between-regions functional connectivity (FC), and assessed the correlation between neuroimaging measures and clinical scores. Finally, the multimodal neuroimaging features were used to differentiate the CS patients and HC individuals by support vector machine (SVM) algorithm. RESULTS: Compared to HC, CS patients had a larger cortical surface area in the right banks of the superior temporal sulcus and rostral anterior cingulate; higher ALFF value in the left inferior frontal gyrus; enhanced FCs between somatomotor and ventral attention network. Three FCs values were associated with clinical pain scores. Furthermore, the three multimodal neuroimaging features with significant differences between groups and the SVM algorithm could classify CS patients and HC with an accuracy of 90.00%. DISCUSSION: Together, our findings revealed extensive reorganization of local functional properties, surface area, and network metrics in CS patients. The success of patient identification highlights the potential of using artificial intelligence and multimodal neuroimaging markers in chronic pain research. Frontiers Media S.A. 2022-11-30 /pmc/articles/PMC9748090/ /pubmed/36532276 http://dx.doi.org/10.3389/fnins.2022.1036487 Text en Copyright © 2022 Wei, Wang, Yu, Lee, Liu, Ren, Tu, Zhou, Shi, Wang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Wei, Xiaoya Wang, Liqiong Yu, Fangting Lee, Chihkai Liu, Ni Ren, Mengmeng Tu, Jianfeng Zhou, Hang Shi, Guangxia Wang, Xu Liu, Cun-Zhi Identifying the neural marker of chronic sciatica using multimodal neuroimaging and machine learning analyses |
title | Identifying the neural marker of chronic sciatica using multimodal neuroimaging and machine learning analyses |
title_full | Identifying the neural marker of chronic sciatica using multimodal neuroimaging and machine learning analyses |
title_fullStr | Identifying the neural marker of chronic sciatica using multimodal neuroimaging and machine learning analyses |
title_full_unstemmed | Identifying the neural marker of chronic sciatica using multimodal neuroimaging and machine learning analyses |
title_short | Identifying the neural marker of chronic sciatica using multimodal neuroimaging and machine learning analyses |
title_sort | identifying the neural marker of chronic sciatica using multimodal neuroimaging and machine learning analyses |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748090/ https://www.ncbi.nlm.nih.gov/pubmed/36532276 http://dx.doi.org/10.3389/fnins.2022.1036487 |
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