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Serum Collagen Triple Helix Repeat Containing-1 Levels are Related to Radiological Affection and Disease Activity in Rheumatoid Arthritis

BACKGROUND: Rheumatoid arthritis (RA) is a common systemic inflammatory disease. Collagen triple helix repeat containing-1 (CTHRC1) is a unique gene product able to reduce collagen deposition. The present study aimed to assess CTHRC1 level in RA patients and to uncover its relation to clinical, labo...

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Autores principales: Nassef, Eman Mostafa, Elabd, Hemmat Ahmed, Elzomor, Hala Mohamed, El Nagger, Basma Mohamed Mohamed Ali, Ibrahim, Amira Shahin, Ibrahim, Amal Hussein, Kotb, Hend Gamal, Hassan, Donia Ahmed, Abd ElAziz, Rasha Elsayed Mohamed, Mohamed, Eman El Sayed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748116/
https://www.ncbi.nlm.nih.gov/pubmed/36532865
http://dx.doi.org/10.2147/OARRR.S391494
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author Nassef, Eman Mostafa
Elabd, Hemmat Ahmed
Elzomor, Hala Mohamed
El Nagger, Basma Mohamed Mohamed Ali
Ibrahim, Amira Shahin
Ibrahim, Amal Hussein
Kotb, Hend Gamal
Hassan, Donia Ahmed
Abd ElAziz, Rasha Elsayed Mohamed
Mohamed, Eman El Sayed
author_facet Nassef, Eman Mostafa
Elabd, Hemmat Ahmed
Elzomor, Hala Mohamed
El Nagger, Basma Mohamed Mohamed Ali
Ibrahim, Amira Shahin
Ibrahim, Amal Hussein
Kotb, Hend Gamal
Hassan, Donia Ahmed
Abd ElAziz, Rasha Elsayed Mohamed
Mohamed, Eman El Sayed
author_sort Nassef, Eman Mostafa
collection PubMed
description BACKGROUND: Rheumatoid arthritis (RA) is a common systemic inflammatory disease. Collagen triple helix repeat containing-1 (CTHRC1) is a unique gene product able to reduce collagen deposition. The present study aimed to assess CTHRC1 level in RA patients and to uncover its relation to clinical, laboratory and radiological findings. METHODS: The study included 60 adult RA patients. In addition, there were 60 control subjects who included patients with osteoarthritis (n = 20) and reactive arthritis (n = 20) and healthy controls (n = 20). Serum CTHRC1 levels were assessed by Enzyme-Linked Immunosorbent Assay (ELISA). Disease activity was calculated using the Disease Activity Score (DAS28-CRP). Radiological damage was evaluated using the Simple Erosion Narrowing Score (SENS). RESULTS: There was significantly higher serum CTHRC1 levels in RA patients when compared to OA, ReA and control groups [median (IQR): 4.66 (1.68–11.7) versus 1.88 (1.14–2.94), 1.55 (0.98–3.15) and 1.14 (0.85–1.3) mg/dL, respectively, p < 0.001]. There was significantly higher CTHRC1 levels in patients with higher disease activity [median (IQR): 2.23 (1.4–4.73) versus 6.55 (4.66–12.0) mg/dL, p = 0.004]. Patients with higher SENS had significantly higher CTHRC1 [median (IQR): 1.99 (1.4–4.66) versus 9.75 (4.39–12.63) mg/dL, p < 0.001] and DAS28 [median (IQR): 4.25 (2.9–5.2) versus 5.4 (4.65–5.8), p = 0.01]. CONCLUSION: Serum CTHRC1 levels are related to disease severity and radiological affection in RA patients.
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spelling pubmed-97481162022-12-15 Serum Collagen Triple Helix Repeat Containing-1 Levels are Related to Radiological Affection and Disease Activity in Rheumatoid Arthritis Nassef, Eman Mostafa Elabd, Hemmat Ahmed Elzomor, Hala Mohamed El Nagger, Basma Mohamed Mohamed Ali Ibrahim, Amira Shahin Ibrahim, Amal Hussein Kotb, Hend Gamal Hassan, Donia Ahmed Abd ElAziz, Rasha Elsayed Mohamed Mohamed, Eman El Sayed Open Access Rheumatol Original Research BACKGROUND: Rheumatoid arthritis (RA) is a common systemic inflammatory disease. Collagen triple helix repeat containing-1 (CTHRC1) is a unique gene product able to reduce collagen deposition. The present study aimed to assess CTHRC1 level in RA patients and to uncover its relation to clinical, laboratory and radiological findings. METHODS: The study included 60 adult RA patients. In addition, there were 60 control subjects who included patients with osteoarthritis (n = 20) and reactive arthritis (n = 20) and healthy controls (n = 20). Serum CTHRC1 levels were assessed by Enzyme-Linked Immunosorbent Assay (ELISA). Disease activity was calculated using the Disease Activity Score (DAS28-CRP). Radiological damage was evaluated using the Simple Erosion Narrowing Score (SENS). RESULTS: There was significantly higher serum CTHRC1 levels in RA patients when compared to OA, ReA and control groups [median (IQR): 4.66 (1.68–11.7) versus 1.88 (1.14–2.94), 1.55 (0.98–3.15) and 1.14 (0.85–1.3) mg/dL, respectively, p < 0.001]. There was significantly higher CTHRC1 levels in patients with higher disease activity [median (IQR): 2.23 (1.4–4.73) versus 6.55 (4.66–12.0) mg/dL, p = 0.004]. Patients with higher SENS had significantly higher CTHRC1 [median (IQR): 1.99 (1.4–4.66) versus 9.75 (4.39–12.63) mg/dL, p < 0.001] and DAS28 [median (IQR): 4.25 (2.9–5.2) versus 5.4 (4.65–5.8), p = 0.01]. CONCLUSION: Serum CTHRC1 levels are related to disease severity and radiological affection in RA patients. Dove 2022-12-09 /pmc/articles/PMC9748116/ /pubmed/36532865 http://dx.doi.org/10.2147/OARRR.S391494 Text en © 2022 Nassef et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Nassef, Eman Mostafa
Elabd, Hemmat Ahmed
Elzomor, Hala Mohamed
El Nagger, Basma Mohamed Mohamed Ali
Ibrahim, Amira Shahin
Ibrahim, Amal Hussein
Kotb, Hend Gamal
Hassan, Donia Ahmed
Abd ElAziz, Rasha Elsayed Mohamed
Mohamed, Eman El Sayed
Serum Collagen Triple Helix Repeat Containing-1 Levels are Related to Radiological Affection and Disease Activity in Rheumatoid Arthritis
title Serum Collagen Triple Helix Repeat Containing-1 Levels are Related to Radiological Affection and Disease Activity in Rheumatoid Arthritis
title_full Serum Collagen Triple Helix Repeat Containing-1 Levels are Related to Radiological Affection and Disease Activity in Rheumatoid Arthritis
title_fullStr Serum Collagen Triple Helix Repeat Containing-1 Levels are Related to Radiological Affection and Disease Activity in Rheumatoid Arthritis
title_full_unstemmed Serum Collagen Triple Helix Repeat Containing-1 Levels are Related to Radiological Affection and Disease Activity in Rheumatoid Arthritis
title_short Serum Collagen Triple Helix Repeat Containing-1 Levels are Related to Radiological Affection and Disease Activity in Rheumatoid Arthritis
title_sort serum collagen triple helix repeat containing-1 levels are related to radiological affection and disease activity in rheumatoid arthritis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748116/
https://www.ncbi.nlm.nih.gov/pubmed/36532865
http://dx.doi.org/10.2147/OARRR.S391494
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