Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells

Post-acute COVID-19 syndrome (PACS) has been defined as symptoms persisting after clearance of a COVID-19 infection. We have previously demonstrated that alterations in DNA methylation (DNAm) status persist in individuals who recovered from a COVID-19 infection, but it is currently unknown if PACS i...

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Autores principales: Nikesjö, Frida, Sayyab, Shumaila, Karlsson, Lovisa, Apostolou, Eirini, Rosén, Anders, Hedman, Kristofer, Lerm, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748378/
https://www.ncbi.nlm.nih.gov/pubmed/36517875
http://dx.doi.org/10.1186/s13148-022-01398-1
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author Nikesjö, Frida
Sayyab, Shumaila
Karlsson, Lovisa
Apostolou, Eirini
Rosén, Anders
Hedman, Kristofer
Lerm, Maria
author_facet Nikesjö, Frida
Sayyab, Shumaila
Karlsson, Lovisa
Apostolou, Eirini
Rosén, Anders
Hedman, Kristofer
Lerm, Maria
author_sort Nikesjö, Frida
collection PubMed
description Post-acute COVID-19 syndrome (PACS) has been defined as symptoms persisting after clearance of a COVID-19 infection. We have previously demonstrated that alterations in DNA methylation (DNAm) status persist in individuals who recovered from a COVID-19 infection, but it is currently unknown if PACS is associated with epigenetic changes. We compared DNAm patterns in patients with PACS with those in controls and in healthy COVID-19 convalescents and found a unique DNAm signature in PACS patients. This signature unravelled modified pathways that regulate angiotensin II and muscarinic receptor signalling and protein–protein interaction networks that have bearings on vesicle formation and mitochondrial function. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13148-022-01398-1.
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spelling pubmed-97483782022-12-14 Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells Nikesjö, Frida Sayyab, Shumaila Karlsson, Lovisa Apostolou, Eirini Rosén, Anders Hedman, Kristofer Lerm, Maria Clin Epigenetics Brief Report Post-acute COVID-19 syndrome (PACS) has been defined as symptoms persisting after clearance of a COVID-19 infection. We have previously demonstrated that alterations in DNA methylation (DNAm) status persist in individuals who recovered from a COVID-19 infection, but it is currently unknown if PACS is associated with epigenetic changes. We compared DNAm patterns in patients with PACS with those in controls and in healthy COVID-19 convalescents and found a unique DNAm signature in PACS patients. This signature unravelled modified pathways that regulate angiotensin II and muscarinic receptor signalling and protein–protein interaction networks that have bearings on vesicle formation and mitochondrial function. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13148-022-01398-1. BioMed Central 2022-12-14 /pmc/articles/PMC9748378/ /pubmed/36517875 http://dx.doi.org/10.1186/s13148-022-01398-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Brief Report
Nikesjö, Frida
Sayyab, Shumaila
Karlsson, Lovisa
Apostolou, Eirini
Rosén, Anders
Hedman, Kristofer
Lerm, Maria
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells
title Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells
title_full Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells
title_fullStr Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells
title_full_unstemmed Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells
title_short Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells
title_sort defining post-acute covid-19 syndrome (pacs) by an epigenetic biosignature in peripheral blood mononuclear cells
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748378/
https://www.ncbi.nlm.nih.gov/pubmed/36517875
http://dx.doi.org/10.1186/s13148-022-01398-1
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