Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones

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An important consequence of infection with a SARS-CoV-2 variant is protective humoral immunity against other variants. However, the basis for such cross-protection at the molecular level is incompletely understood. Here, we characterized the repertoire and epitope specificity of antibodies elicited...

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Autores principales: Lima, Noemia S., Musayev, Maryam, Johnston, Timothy S., Wagner, Danielle A., Henry, Amy R., Wang, Lingshu, Yang, Eun Sung, Zhang, Yi, Birungi, Kevina, Black, Walker P., O’Dell, Sijy, Schmidt, Stephen D., Moon, Damee, Lorang, Cynthia G., Zhao, Bingchun, Chen, Man, Boswell, Kristin L., Roberts-Torres, Jesmine, Davis, Rachel L., Peyton, Lowrey, Narpala, Sandeep R., O’Connell, Sarah, Serebryannyy, Leonid, Wang, Jennifer, Schrager, Alexander, Talana, Chloe Adrienna, Shimberg, Geoffrey, Leung, Kwanyee, Shi, Wei, Khashab, Rawan, Biber, Asaf, Zilberman, Tal, Rhein, Joshua, Vetter, Sara, Ahmed, Afeefa, Novik, Laura, Widge, Alicia, Gordon, Ingelise, Guech, Mercy, Teng, I-Ting, Phung, Emily, Ruckwardt, Tracy J., Pegu, Amarendra, Misasi, John, Doria-Rose, Nicole A., Gaudinski, Martin, Koup, Richard A., Kwong, Peter D., McDermott, Adrian B., Amit, Sharon, Schacker, Timothy W., Levy, Itzchak, Mascola, John R., Sullivan, Nancy J., Schramm, Chaim A., Douek, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748393/
https://www.ncbi.nlm.nih.gov/pubmed/36517467
http://dx.doi.org/10.1038/s41467-022-35456-2
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