Cargando…

BPTF promotes the progression of distinct subtypes of breast cancer and is a therapeutic target

PURPOSE: To assess the biomarker and functional role of the chromatin remodeling factor, bromodomain PHD finger transcription factor (BPTF), in breast cancer progression. METHODS: BPTF copy number was assessed using fluorescence in situ hybridization. BPTF expression was regulated in breast cancer c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bezrookove, Vladimir, Khan, Imran A., Nosrati, Mehdi, Miller, James R., McAllister, Sean, Dar, Altaf A., Kashani-Sabet, Mohammed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748419/ https://www.ncbi.nlm.nih.gov/pubmed/36530982 http://dx.doi.org/10.3389/fonc.2022.1011173

Ejemplares similares

The Role of BPTF in Melanoma Progression and in Response to BRAF-Targeted Therapy
por: Dar, Altaf A., et al.
Publicado: (2015)

Bromodomain inhibition overcomes treatment resistance in distinct molecular subtypes of melanoma
por: Dar, Altaf A., et al.
Publicado: (2022)

Niraparib Suppresses Cholangiocarcinoma Tumor Growth by Inducing Oxidative and Replication Stress
por: Bezrookove, Vladimir, et al.
Publicado: (2021)

Tumor suppressor role of microRNA-1296 in triple-negative breast cancer
por: Phan, Binh, et al.
Publicado: (2016)

Dinaciclib, a cyclin-dependent kinase inhibitor, suppresses cholangiocarcinoma growth by targeting CDK2/5/9
por: Saqub, Hera, et al.
Publicado: (2020)

Novel tumor suppressor role of miRNA-876 in cholangiocarcinoma
por: Ursu, Sarah, et al.
Publicado: (2019)

The Role of miR-18b in MDM2-p53 Pathway Signaling and Melanoma Progression
por: Dar, Altaf A, et al.
Publicado: (2013)

Prognostic Impact of PHIP Copy Number in Melanoma: Linkage to Ulceration
por: Bezrookove, Vladimir, et al.
Publicado: (2013)

PHIPing along: Evolution of PHIP as a cancer biomarker and a target for therapy
por: Kashani-Sabet, Mohammed, et al.
Publicado: (2018)

BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis
por: Richart, Laia, et al.
Publicado: (2016)

BPTF promotes tumor growth and predicts poor prognosis in lung adenocarcinomas
por: Dai, Meng, et al.
Publicado: (2015)

Pitfalls and Rewards of Setting Up a Liquid Biopsy Approach for the Detection of Driver Mutations in Circulating Tumor DNAs: Our Institutional Experience
por: Chen, Michelle, et al.
Publicado: (2022)

The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome
por: Morrison, Emma A, et al.
Publicado: (2018)

HCMV glycoprotein B is expressed in primary glioblastomas and enhances growth and invasiveness via PDGFR-alpha activation
por: Cobbs, Charles, et al.
Publicado: (2014)

BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells
por: Frey, Wesley D., et al.
Publicado: (2017)

BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands
por: Mayes, Kimberly, et al.
Publicado: (2017)

BPTF Regulates Growth of Adult and Pediatric High-Grade Glioma through the MYC Pathway
por: Green, Adam L., et al.
Publicado: (2019)

Phenotypic expansion of the BPTF‐related neurodevelopmental disorder with dysmorphic facies and distal limb anomalies
por: Glinton, Kevin E., et al.
Publicado: (2021)

BPTF inhibition antagonizes colorectal cancer progression by transcriptionally inactivating Cdc25A
por: Guo, Ping, et al.
Publicado: (2022)

Identification of Distinct Immune Subtypes in Colorectal Cancer Based on the Stromal Compartment
por: Shen, Rongfang, et al.
Publicado: (2020)

Essential Role of Chromatin Remodeling Protein Bptf in Early Mouse Embryos and Embryonic Stem Cells
por: Landry, Joseph, et al.
Publicado: (2008)

Dual Targeting of EGFR and MTOR Pathways Inhibits Glioblastoma Growth by Modulating the Tumor Microenvironment
por: Sidorov, Maxim, et al.
Publicado: (2023)

m(6)A Regulator Expression Segregates Meningiomas Into Biologically Distinct Subtypes
por: Chen, Jiawei, et al.
Publicado: (2021)

Drug responses are conserved across patient-derived xenograft models of melanoma leading to identification of novel drug combination therapies
por: Ice, Ryan J., et al.
Publicado: (2019)

A Novel Translocation Breakpoint within the BPTF Gene Is Associated with a Pre-Malignant Phenotype
por: Buganim, Yosef, et al.
Publicado: (2010)

BPTF activates the MAPK pathway through coexpression with Raf1 to promote proliferation of T-cell lymphoma
por: Bai, Dongyu, et al.
Publicado: (2022)

Two Distinct Subtypes Revealed in Blood Transcriptome of Breast Cancer Patients With an Unsupervised Analysis
por: Ming, Wenlong, et al.
Publicado: (2019)

Nanometer-scale distribution of PD-1 in the melanoma tumor microenvironment
por: Comerci, Colin J, et al.
Publicado: (2023)

Transcriptomic Analysis Identified Two Subtypes of Brain Tumor Characterized by Distinct Immune Infiltration and Prognosis
por: Shen, Xilin, et al.
Publicado: (2021)

Genomic Landscape in Neoplasm-Like Stroma Reveals Distinct Prognostic Subtypes of Pancreatic Ductal Adenocarcinoma
por: Jiang, Jiahong, et al.
Publicado: (2021)

Transcriptomic signature defines two subtypes of locally advanced PCa with distinct neoadjuvant therapy benefits
por: Zhu, Yinjie, et al.
Publicado: (2023)

BPTF promotes hepatocellular carcinoma growth by modulating hTERT signaling and cancer stem cell traits
por: Zhao, Xinrui, et al.
Publicado: (2018)

Targeting regulation of VEGF by BPTF in non-small cell lung cancer and its potential clinical significance
por: Dai, Meng, et al.
Publicado: (2022)

PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer
por: Gao, Sheng, et al.
Publicado: (2023)

Leukemia With TCF3-ZNF384 Rearrangement as a Distinct Subtype of Disease With Distinct Treatments: Perspectives From A Case Report and Literature Review
por: Lin, Na, et al.
Publicado: (2021)

Distinctive modulation of hepcidin in cancer and its therapeutic relevance
por: Lin, Feng, et al.
Publicado: (2023)

Reveal the Heterogeneity in the Tumor Microenvironment of Pancreatic Cancer and Analyze the Differences in Prognosis and Immunotherapy Responses of Distinct Immune Subtypes
por: Wang, Xiaoqin, et al.
Publicado: (2022)

Targeting BPTF Sensitizes Pancreatic Ductal Adenocarcinoma to Chemotherapy by Repressing ABC-Transporters and Impairing Multidrug Resistance (MDR)
por: Muñoz Velasco, Raúl, et al.
Publicado: (2022)

Hepatocellular carcinoma subtypes based on metabolic pathways reveals potential therapeutic targets
por: He, Zehua, et al.
Publicado: (2023)

Unraveling tumor microenvironment heterogeneity in malignant pleural mesothelioma identifies biologically distinct immune subtypes enabling prognosis determination
por: Yang, Kaidi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_i30eek5i46qvfiru6jrktn581l