Allosteric activation of preformed EGF receptor dimers by a single ligand binding event

Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated in a variety of human cancers. Elucidation of the structure of the full-length receptor is essential to understand the molecular mechanisms underlying its activation. Unlike previously anticipated, he...

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Detalles Bibliográficos
Autores principales: Purba, Endang R., Saita, Ei-ichiro, Akhouri, Reetesh R., Öfverstedt, Lars-Goran, Wilken, Gunnar, Skoglund, Ulf, Maruyama, Ichiro N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748436/
https://www.ncbi.nlm.nih.gov/pubmed/36531494
http://dx.doi.org/10.3389/fendo.2022.1042787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748436/
https://www.ncbi.nlm.nih.gov/pubmed/36531494
http://dx.doi.org/10.3389/fendo.2022.1042787

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