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Understanding Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement

Metabolism and movement, among the critical determinants in the survival and success of an organism, are tightly regulated by the brain and skeletal muscle. At the cellular level, mitochondria -that powers life, and myosin - the molecular motor of the cell, have both evolved to serve this purpose. A...

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Detalles Bibliográficos
Autores principales: Jena, Bhanu P., Larsson, Lars, Gatti, Domenico L., Ghiran, Ionita, Cho, Won Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Applied Systems srl 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748637/
https://www.ncbi.nlm.nih.gov/pubmed/36530835
http://dx.doi.org/10.15190/d.2022.3
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author Jena, Bhanu P.
Larsson, Lars
Gatti, Domenico L.
Ghiran, Ionita
Cho, Won Jin
author_facet Jena, Bhanu P.
Larsson, Lars
Gatti, Domenico L.
Ghiran, Ionita
Cho, Won Jin
author_sort Jena, Bhanu P.
collection PubMed
description Metabolism and movement, among the critical determinants in the survival and success of an organism, are tightly regulated by the brain and skeletal muscle. At the cellular level, mitochondria -that powers life, and myosin - the molecular motor of the cell, have both evolved to serve this purpose. Although independently, the skeletal muscle and brain have been intensively investigated for over a century, their coordinated involvement in metabolism and movement remains poorly understood. Therefore, a fundamental understanding of the coordinated involvement of the brain and skeletal muscle in metabolism and movement holds great promise in providing a window to a wide range of life processes and in the development of tools and approaches in disease detection and therapy. Recent developments in new tools, technologies and approaches, and advances in computing power and machine learning, provides for the first time the opportunity to establish a new field of study, the ‘Science and Engineering of Metabolism and Movement’. This new field of study could provide substantial new insights and breakthrough into how metabolism and movement is governed at the systems level in an organism. The design and approach to accomplish this objective is briefly discussed in this article.
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spelling pubmed-97486372022-12-15 Understanding Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement Jena, Bhanu P. Larsson, Lars Gatti, Domenico L. Ghiran, Ionita Cho, Won Jin Discoveries (Craiova) Perspective Article Metabolism and movement, among the critical determinants in the survival and success of an organism, are tightly regulated by the brain and skeletal muscle. At the cellular level, mitochondria -that powers life, and myosin - the molecular motor of the cell, have both evolved to serve this purpose. Although independently, the skeletal muscle and brain have been intensively investigated for over a century, their coordinated involvement in metabolism and movement remains poorly understood. Therefore, a fundamental understanding of the coordinated involvement of the brain and skeletal muscle in metabolism and movement holds great promise in providing a window to a wide range of life processes and in the development of tools and approaches in disease detection and therapy. Recent developments in new tools, technologies and approaches, and advances in computing power and machine learning, provides for the first time the opportunity to establish a new field of study, the ‘Science and Engineering of Metabolism and Movement’. This new field of study could provide substantial new insights and breakthrough into how metabolism and movement is governed at the systems level in an organism. The design and approach to accomplish this objective is briefly discussed in this article. Applied Systems srl 2022-03-01 /pmc/articles/PMC9748637/ /pubmed/36530835 http://dx.doi.org/10.15190/d.2022.3 Text en Copyright © 2022, Jena BP et al., Applied Systems and Discoveries Journals. https://creativecommons.org/licenses/by/4.0/This article is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited and it is not used for commercial purposes.
spellingShingle Perspective Article
Jena, Bhanu P.
Larsson, Lars
Gatti, Domenico L.
Ghiran, Ionita
Cho, Won Jin
Understanding Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement
title Understanding Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement
title_full Understanding Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement
title_fullStr Understanding Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement
title_full_unstemmed Understanding Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement
title_short Understanding Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement
title_sort understanding brain-skeletal muscle crosstalk impacting metabolism and movement
topic Perspective Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748637/
https://www.ncbi.nlm.nih.gov/pubmed/36530835
http://dx.doi.org/10.15190/d.2022.3
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