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Niobium carbide–mediated photothermal therapy for infected wound treatment

Bacterial infections of the wounds on the skin surface significantly reduce the rate of wound healing, potentially leading to serious systemic infections. Antibiotics are the first-line drugs for the treatment of these infections. However, the misuse and overuse of antibiotics have led to the emerge...

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Autores principales: Ren, Junyu, Da, Junlong, Wu, Wei, Zheng, Ce, Hu, Narisu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748739/
https://www.ncbi.nlm.nih.gov/pubmed/36532585
http://dx.doi.org/10.3389/fbioe.2022.934981
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author Ren, Junyu
Da, Junlong
Wu, Wei
Zheng, Ce
Hu, Narisu
author_facet Ren, Junyu
Da, Junlong
Wu, Wei
Zheng, Ce
Hu, Narisu
author_sort Ren, Junyu
collection PubMed
description Bacterial infections of the wounds on the skin surface significantly reduce the rate of wound healing, potentially leading to serious systemic infections. Antibiotics are the first-line drugs for the treatment of these infections. However, the misuse and overuse of antibiotics have led to the emergence of bacterial resistance. Therefore, a new antimicrobial strategy is urgently needed. Photothermal therapy (PTT) is a novel efficient therapeutic technique that can produce irreversible cell damage to induce death of bacteria, possessing a great potential in infected wound healing. This work describes the use of a new photothermal agent (PTA) such as niobium carbide (NbC) nanoparticles with outstanding near-infrared (NIR) absorption property. NbC nanoparticles converted NIR laser irradiation energy into localized heat for photothermal treatment. In vitro antimicrobial experiments have revealed that NbC nanoparticles exert excellent antimicrobial effects against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Moreover, NbC nanoparticles accelerated E. coli–infected wound healing process, reduced inflammatory response, and showed good biosafety in vivo. Altogether, NbC nanoparticles represent an efficient PTA for antimicrobial treatment and are a bio-safe material with low toxicity in vivo.
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spelling pubmed-97487392022-12-15 Niobium carbide–mediated photothermal therapy for infected wound treatment Ren, Junyu Da, Junlong Wu, Wei Zheng, Ce Hu, Narisu Front Bioeng Biotechnol Bioengineering and Biotechnology Bacterial infections of the wounds on the skin surface significantly reduce the rate of wound healing, potentially leading to serious systemic infections. Antibiotics are the first-line drugs for the treatment of these infections. However, the misuse and overuse of antibiotics have led to the emergence of bacterial resistance. Therefore, a new antimicrobial strategy is urgently needed. Photothermal therapy (PTT) is a novel efficient therapeutic technique that can produce irreversible cell damage to induce death of bacteria, possessing a great potential in infected wound healing. This work describes the use of a new photothermal agent (PTA) such as niobium carbide (NbC) nanoparticles with outstanding near-infrared (NIR) absorption property. NbC nanoparticles converted NIR laser irradiation energy into localized heat for photothermal treatment. In vitro antimicrobial experiments have revealed that NbC nanoparticles exert excellent antimicrobial effects against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Moreover, NbC nanoparticles accelerated E. coli–infected wound healing process, reduced inflammatory response, and showed good biosafety in vivo. Altogether, NbC nanoparticles represent an efficient PTA for antimicrobial treatment and are a bio-safe material with low toxicity in vivo. Frontiers Media S.A. 2022-11-30 /pmc/articles/PMC9748739/ /pubmed/36532585 http://dx.doi.org/10.3389/fbioe.2022.934981 Text en Copyright © 2022 Ren, Da, Wu, Zheng and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Ren, Junyu
Da, Junlong
Wu, Wei
Zheng, Ce
Hu, Narisu
Niobium carbide–mediated photothermal therapy for infected wound treatment
title Niobium carbide–mediated photothermal therapy for infected wound treatment
title_full Niobium carbide–mediated photothermal therapy for infected wound treatment
title_fullStr Niobium carbide–mediated photothermal therapy for infected wound treatment
title_full_unstemmed Niobium carbide–mediated photothermal therapy for infected wound treatment
title_short Niobium carbide–mediated photothermal therapy for infected wound treatment
title_sort niobium carbide–mediated photothermal therapy for infected wound treatment
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748739/
https://www.ncbi.nlm.nih.gov/pubmed/36532585
http://dx.doi.org/10.3389/fbioe.2022.934981
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