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Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective

Biofilms are consortia of microorganisms that form collectives through the excretion of extracellular matrix compounds. The importance of biofilms in biological, industrial and medical settings has long been recognized due to their emergent properties and impact on surrounding environments. In labor...

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Detalles Bibliográficos
Autores principales: Eigentler, Lukas, Davidson, Fordyce A., Stanley-Wall, Nicola R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748781/
https://www.ncbi.nlm.nih.gov/pubmed/36514980
http://dx.doi.org/10.1098/rsob.220194
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author Eigentler, Lukas
Davidson, Fordyce A.
Stanley-Wall, Nicola R.
author_facet Eigentler, Lukas
Davidson, Fordyce A.
Stanley-Wall, Nicola R.
author_sort Eigentler, Lukas
collection PubMed
description Biofilms are consortia of microorganisms that form collectives through the excretion of extracellular matrix compounds. The importance of biofilms in biological, industrial and medical settings has long been recognized due to their emergent properties and impact on surrounding environments. In laboratory situations, one commonly used approach to study biofilm formation mechanisms is the colony biofilm assay, in which cell communities grow on solid–gas interfaces on agar plates after the deposition of a population of founder cells. The residents of a colony biofilm can self-organize to form intricate spatial distributions. The assay is ideally suited to coupling with mathematical modelling due to the ability to extract a wide range of metrics. In this review, we highlight how interdisciplinary approaches have provided deep insights into mechanisms causing the emergence of these spatial distributions from well-mixed inocula.
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spelling pubmed-97487812022-12-16 Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective Eigentler, Lukas Davidson, Fordyce A. Stanley-Wall, Nicola R. Open Biol Review Biofilms are consortia of microorganisms that form collectives through the excretion of extracellular matrix compounds. The importance of biofilms in biological, industrial and medical settings has long been recognized due to their emergent properties and impact on surrounding environments. In laboratory situations, one commonly used approach to study biofilm formation mechanisms is the colony biofilm assay, in which cell communities grow on solid–gas interfaces on agar plates after the deposition of a population of founder cells. The residents of a colony biofilm can self-organize to form intricate spatial distributions. The assay is ideally suited to coupling with mathematical modelling due to the ability to extract a wide range of metrics. In this review, we highlight how interdisciplinary approaches have provided deep insights into mechanisms causing the emergence of these spatial distributions from well-mixed inocula. The Royal Society 2022-12-14 /pmc/articles/PMC9748781/ /pubmed/36514980 http://dx.doi.org/10.1098/rsob.220194 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Review
Eigentler, Lukas
Davidson, Fordyce A.
Stanley-Wall, Nicola R.
Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective
title Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective
title_full Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective
title_fullStr Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective
title_full_unstemmed Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective
title_short Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective
title_sort mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748781/
https://www.ncbi.nlm.nih.gov/pubmed/36514980
http://dx.doi.org/10.1098/rsob.220194
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