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Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective
Biofilms are consortia of microorganisms that form collectives through the excretion of extracellular matrix compounds. The importance of biofilms in biological, industrial and medical settings has long been recognized due to their emergent properties and impact on surrounding environments. In labor...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748781/ https://www.ncbi.nlm.nih.gov/pubmed/36514980 http://dx.doi.org/10.1098/rsob.220194 |
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author | Eigentler, Lukas Davidson, Fordyce A. Stanley-Wall, Nicola R. |
author_facet | Eigentler, Lukas Davidson, Fordyce A. Stanley-Wall, Nicola R. |
author_sort | Eigentler, Lukas |
collection | PubMed |
description | Biofilms are consortia of microorganisms that form collectives through the excretion of extracellular matrix compounds. The importance of biofilms in biological, industrial and medical settings has long been recognized due to their emergent properties and impact on surrounding environments. In laboratory situations, one commonly used approach to study biofilm formation mechanisms is the colony biofilm assay, in which cell communities grow on solid–gas interfaces on agar plates after the deposition of a population of founder cells. The residents of a colony biofilm can self-organize to form intricate spatial distributions. The assay is ideally suited to coupling with mathematical modelling due to the ability to extract a wide range of metrics. In this review, we highlight how interdisciplinary approaches have provided deep insights into mechanisms causing the emergence of these spatial distributions from well-mixed inocula. |
format | Online Article Text |
id | pubmed-9748781 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-97487812022-12-16 Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective Eigentler, Lukas Davidson, Fordyce A. Stanley-Wall, Nicola R. Open Biol Review Biofilms are consortia of microorganisms that form collectives through the excretion of extracellular matrix compounds. The importance of biofilms in biological, industrial and medical settings has long been recognized due to their emergent properties and impact on surrounding environments. In laboratory situations, one commonly used approach to study biofilm formation mechanisms is the colony biofilm assay, in which cell communities grow on solid–gas interfaces on agar plates after the deposition of a population of founder cells. The residents of a colony biofilm can self-organize to form intricate spatial distributions. The assay is ideally suited to coupling with mathematical modelling due to the ability to extract a wide range of metrics. In this review, we highlight how interdisciplinary approaches have provided deep insights into mechanisms causing the emergence of these spatial distributions from well-mixed inocula. The Royal Society 2022-12-14 /pmc/articles/PMC9748781/ /pubmed/36514980 http://dx.doi.org/10.1098/rsob.220194 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Review Eigentler, Lukas Davidson, Fordyce A. Stanley-Wall, Nicola R. Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective |
title | Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective |
title_full | Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective |
title_fullStr | Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective |
title_full_unstemmed | Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective |
title_short | Mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective |
title_sort | mechanisms driving spatial distribution of residents in colony biofilms: an interdisciplinary perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748781/ https://www.ncbi.nlm.nih.gov/pubmed/36514980 http://dx.doi.org/10.1098/rsob.220194 |
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