Cargando…
Evaluation of serum neopterin, periostin, Tenascin‐C, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-2 levels in obese pregnant women
OBJECTIVE: To investigate the role of extracellular matrix proteins in the molecular mechanism of inflammatory response in obese pregnant women by comparing serum levels of neopterin, periostin, Tenascin-C, tissue inhibitor of metalloproteinase-1, and matrix metalloproteinase-2 between obese and nor...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748859/ https://www.ncbi.nlm.nih.gov/pubmed/36511564 http://dx.doi.org/10.4274/tjod.galenos.2022.70593 |
_version_ | 1784849916780085248 |
---|---|
author | Melekoğlu, Rauf Ünüvar, Songül Türkmen, Neşe Başak Çetin, Aslı Zeyveli Çelik, Nesibe Yüce, Hande Yaşar, Şeyma |
author_facet | Melekoğlu, Rauf Ünüvar, Songül Türkmen, Neşe Başak Çetin, Aslı Zeyveli Çelik, Nesibe Yüce, Hande Yaşar, Şeyma |
author_sort | Melekoğlu, Rauf |
collection | PubMed |
description | OBJECTIVE: To investigate the role of extracellular matrix proteins in the molecular mechanism of inflammatory response in obese pregnant women by comparing serum levels of neopterin, periostin, Tenascin-C, tissue inhibitor of metalloproteinase-1, and matrix metalloproteinase-2 between obese and normal weight pregnant women in the third trimester. MATERIALS AND METHODS: A prospective cross-sectional study was conducted between April 2021 and December 2021. A total of 84 pregnant women were included and three groups were formed with 28 participants in each group. RESULTS: Serum levels of neopterin, periostin, Tenascin-C and tissue inhibitor of metalloproteinase-1 were significantly higher in class II-III obese pregnant women than in class I obese and normal-weight women (p=0.002, p<0.001, p<0.001, and p<0.001, respectively). There was no significant difference in serum matrix metalloproteinase-2 levels between the groups (p=0.769). Receiver operating characteristic curve analysis showed that Tenascin-C and periostin were effective in predicting pre-eclampsia [area under the curve (AUC)=0.82, 95% confidence interval (CI), 0.72-0.90, p<0.001 and AUC=0.71, 95% CI, 0.60-0.80, p=0.007, respectively]. CONCLUSION: This study demonstrated that class II-III obese pregnant women had significantly higher serum levels of neopterin, periostin, Tenascin-C, and tissue inhibitor of metalloproteinase-1 in the third trimester. These higher serum levels may be associated with the adverse perinatal effects of obesity during pregnancy. |
format | Online Article Text |
id | pubmed-9748859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-97488592022-12-21 Evaluation of serum neopterin, periostin, Tenascin‐C, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-2 levels in obese pregnant women Melekoğlu, Rauf Ünüvar, Songül Türkmen, Neşe Başak Çetin, Aslı Zeyveli Çelik, Nesibe Yüce, Hande Yaşar, Şeyma Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: To investigate the role of extracellular matrix proteins in the molecular mechanism of inflammatory response in obese pregnant women by comparing serum levels of neopterin, periostin, Tenascin-C, tissue inhibitor of metalloproteinase-1, and matrix metalloproteinase-2 between obese and normal weight pregnant women in the third trimester. MATERIALS AND METHODS: A prospective cross-sectional study was conducted between April 2021 and December 2021. A total of 84 pregnant women were included and three groups were formed with 28 participants in each group. RESULTS: Serum levels of neopterin, periostin, Tenascin-C and tissue inhibitor of metalloproteinase-1 were significantly higher in class II-III obese pregnant women than in class I obese and normal-weight women (p=0.002, p<0.001, p<0.001, and p<0.001, respectively). There was no significant difference in serum matrix metalloproteinase-2 levels between the groups (p=0.769). Receiver operating characteristic curve analysis showed that Tenascin-C and periostin were effective in predicting pre-eclampsia [area under the curve (AUC)=0.82, 95% confidence interval (CI), 0.72-0.90, p<0.001 and AUC=0.71, 95% CI, 0.60-0.80, p=0.007, respectively]. CONCLUSION: This study demonstrated that class II-III obese pregnant women had significantly higher serum levels of neopterin, periostin, Tenascin-C, and tissue inhibitor of metalloproteinase-1 in the third trimester. These higher serum levels may be associated with the adverse perinatal effects of obesity during pregnancy. Galenos Publishing 2022-12 2022-12-13 /pmc/articles/PMC9748859/ /pubmed/36511564 http://dx.doi.org/10.4274/tjod.galenos.2022.70593 Text en ©Copyright 2022 by Turkish Society of Obstetrics and Gynecology | Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Investigation Melekoğlu, Rauf Ünüvar, Songül Türkmen, Neşe Başak Çetin, Aslı Zeyveli Çelik, Nesibe Yüce, Hande Yaşar, Şeyma Evaluation of serum neopterin, periostin, Tenascin‐C, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-2 levels in obese pregnant women |
title | Evaluation of serum neopterin, periostin, Tenascin‐C, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-2 levels in obese pregnant women |
title_full | Evaluation of serum neopterin, periostin, Tenascin‐C, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-2 levels in obese pregnant women |
title_fullStr | Evaluation of serum neopterin, periostin, Tenascin‐C, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-2 levels in obese pregnant women |
title_full_unstemmed | Evaluation of serum neopterin, periostin, Tenascin‐C, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-2 levels in obese pregnant women |
title_short | Evaluation of serum neopterin, periostin, Tenascin‐C, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-2 levels in obese pregnant women |
title_sort | evaluation of serum neopterin, periostin, tenascin‐c, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-2 levels in obese pregnant women |
topic | Clinical Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748859/ https://www.ncbi.nlm.nih.gov/pubmed/36511564 http://dx.doi.org/10.4274/tjod.galenos.2022.70593 |
work_keys_str_mv | AT melekoglurauf evaluationofserumneopterinperiostintenascinctissueinhibitorofmetalloproteinase1andmatrixmetalloproteinase2levelsinobesepregnantwomen AT unuvarsongul evaluationofserumneopterinperiostintenascinctissueinhibitorofmetalloproteinase1andmatrixmetalloproteinase2levelsinobesepregnantwomen AT turkmennesebasak evaluationofserumneopterinperiostintenascinctissueinhibitorofmetalloproteinase1andmatrixmetalloproteinase2levelsinobesepregnantwomen AT cetinaslı evaluationofserumneopterinperiostintenascinctissueinhibitorofmetalloproteinase1andmatrixmetalloproteinase2levelsinobesepregnantwomen AT zeyveliceliknesibe evaluationofserumneopterinperiostintenascinctissueinhibitorofmetalloproteinase1andmatrixmetalloproteinase2levelsinobesepregnantwomen AT yucehande evaluationofserumneopterinperiostintenascinctissueinhibitorofmetalloproteinase1andmatrixmetalloproteinase2levelsinobesepregnantwomen AT yasarseyma evaluationofserumneopterinperiostintenascinctissueinhibitorofmetalloproteinase1andmatrixmetalloproteinase2levelsinobesepregnantwomen |