Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells

Estrogen receptor alpha (ERα) is a ligand-dependent master transcriptional regulator and key driver of breast cancer pathology. Small molecule hormones and competitive antagonists favor unique ERα conformational ensembles that elicit ligand-specific transcriptional programs in breast cancer and othe...

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Bibliografiske detaljer
Autores principales: Hancock, G. R., Young, K. S., Hosfield, D. J., Joiner, C., Sullivan, E. A., Yildiz, Y., Lainé, M., Greene, G. L., Fanning, S. W.
Format: Online Artículo Texto
Sprog:English
Udgivet: Nature Publishing Group UK 2022
Fag:
Article
Online adgang:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748900/
https://www.ncbi.nlm.nih.gov/pubmed/36517522
http://dx.doi.org/10.1038/s41523-022-00497-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748900/
https://www.ncbi.nlm.nih.gov/pubmed/36517522
http://dx.doi.org/10.1038/s41523-022-00497-9

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