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Early riser specific immune cell response by delayed-type hypersensitivity in a kidney transplant patient vaccinated against COVID-19

We present a female kidney transplant patient under conventional immunosuppression therapy. Her humoral immunity study (anti-spike-specific antibodies) was negative after the initial regimen and the third dose of vaccination against COVID-19. The specific ex vivo cellular immune study against spike...

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Autores principales: Barrios, Yvelise, Alava-Cruz, Cristina, Marrero-Miranda, Domingo, Matheu, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748959/
https://www.ncbi.nlm.nih.gov/pubmed/36524267
http://dx.doi.org/10.1136/bcr-2022-250509
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author Barrios, Yvelise
Alava-Cruz, Cristina
Marrero-Miranda, Domingo
Matheu, Victor
author_facet Barrios, Yvelise
Alava-Cruz, Cristina
Marrero-Miranda, Domingo
Matheu, Victor
author_sort Barrios, Yvelise
collection PubMed
description We present a female kidney transplant patient under conventional immunosuppression therapy. Her humoral immunity study (anti-spike-specific antibodies) was negative after the initial regimen and the third dose of vaccination against COVID-19. The specific ex vivo cellular immune study against spike of SARS-CoV-2 by interferon gamma release assay (IGRA) also remained at non-response levels at different time points despite an optimal non-specific cell immune response assessment. However, the cellular immunity test by delayed-type hypersensitivity (DTH) with spike of SARS-CoV-2 was always positive since the vaccination scheme began. Only after COVID-19 infection has there been a seroconversion of the patient’s antibody tests along with IGRA positivity. The use of DTH test to measure the immune response could be a better and earlier parameter of the actual immune status that helps us to predict the immune response in real life. Hybrid immunity combining vaccine and natural infection could be a stronger stimulator of the specific global immune response.
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spelling pubmed-97489592022-12-15 Early riser specific immune cell response by delayed-type hypersensitivity in a kidney transplant patient vaccinated against COVID-19 Barrios, Yvelise Alava-Cruz, Cristina Marrero-Miranda, Domingo Matheu, Victor BMJ Case Rep Case Reports: Novel diagnostic procedure We present a female kidney transplant patient under conventional immunosuppression therapy. Her humoral immunity study (anti-spike-specific antibodies) was negative after the initial regimen and the third dose of vaccination against COVID-19. The specific ex vivo cellular immune study against spike of SARS-CoV-2 by interferon gamma release assay (IGRA) also remained at non-response levels at different time points despite an optimal non-specific cell immune response assessment. However, the cellular immunity test by delayed-type hypersensitivity (DTH) with spike of SARS-CoV-2 was always positive since the vaccination scheme began. Only after COVID-19 infection has there been a seroconversion of the patient’s antibody tests along with IGRA positivity. The use of DTH test to measure the immune response could be a better and earlier parameter of the actual immune status that helps us to predict the immune response in real life. Hybrid immunity combining vaccine and natural infection could be a stronger stimulator of the specific global immune response. BMJ Publishing Group 2022-12-13 /pmc/articles/PMC9748959/ /pubmed/36524267 http://dx.doi.org/10.1136/bcr-2022-250509 Text en © BMJ Publishing Group Limited 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Reports: Novel diagnostic procedure
Barrios, Yvelise
Alava-Cruz, Cristina
Marrero-Miranda, Domingo
Matheu, Victor
Early riser specific immune cell response by delayed-type hypersensitivity in a kidney transplant patient vaccinated against COVID-19
title Early riser specific immune cell response by delayed-type hypersensitivity in a kidney transplant patient vaccinated against COVID-19
title_full Early riser specific immune cell response by delayed-type hypersensitivity in a kidney transplant patient vaccinated against COVID-19
title_fullStr Early riser specific immune cell response by delayed-type hypersensitivity in a kidney transplant patient vaccinated against COVID-19
title_full_unstemmed Early riser specific immune cell response by delayed-type hypersensitivity in a kidney transplant patient vaccinated against COVID-19
title_short Early riser specific immune cell response by delayed-type hypersensitivity in a kidney transplant patient vaccinated against COVID-19
title_sort early riser specific immune cell response by delayed-type hypersensitivity in a kidney transplant patient vaccinated against covid-19
topic Case Reports: Novel diagnostic procedure
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748959/
https://www.ncbi.nlm.nih.gov/pubmed/36524267
http://dx.doi.org/10.1136/bcr-2022-250509
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