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Infertility in systemic lupus erythematosus: what rheumatologists need to know in a new age of assisted reproductive technology

Fertility is often a concern for women with SLE. In addition to known indirect factors that influence the ability of a woman with SLE to become pregnant, such as cytotoxic agents, other medications, advanced age and psychosocial effects of the disease, direct disease-related factors are believed to...

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Autores principales: Stamm, Bessie, Barbhaiya, Medha, Siegel, Caroline, Lieber, Sarah, Lockshin, Michael, Sammaritano, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748971/
https://www.ncbi.nlm.nih.gov/pubmed/36600642
http://dx.doi.org/10.1136/lupus-2022-000840
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author Stamm, Bessie
Barbhaiya, Medha
Siegel, Caroline
Lieber, Sarah
Lockshin, Michael
Sammaritano, Lisa
author_facet Stamm, Bessie
Barbhaiya, Medha
Siegel, Caroline
Lieber, Sarah
Lockshin, Michael
Sammaritano, Lisa
author_sort Stamm, Bessie
collection PubMed
description Fertility is often a concern for women with SLE. In addition to known indirect factors that influence the ability of a woman with SLE to become pregnant, such as cytotoxic agents, other medications, advanced age and psychosocial effects of the disease, direct disease-related factors are believed to influence fertility. These include diminished ovarian reserve, menstrual irregularities (a function of disease activity) and the presence of antiphospholipid antibodies. The question of whether SLE intrinsically affects fertility, however, remains unanswered. In this review, we address known factors affecting fertility, assess current data regarding a direct impact of SLE on fertility and evaluate potential disease-related risk factors. We focus primarily on studies measuring anti-Müllerian hormone and antral follicle count, the most widely measured markers of ovarian reserve. Our goal is to provide information to rheumatologists faced with counselling patients with SLE regarding their fertility, family planning and options for assisted reproductive technologies, which now include fertility preservation through oocyte cryopreservation.
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spelling pubmed-97489712022-12-15 Infertility in systemic lupus erythematosus: what rheumatologists need to know in a new age of assisted reproductive technology Stamm, Bessie Barbhaiya, Medha Siegel, Caroline Lieber, Sarah Lockshin, Michael Sammaritano, Lisa Lupus Sci Med Review Fertility is often a concern for women with SLE. In addition to known indirect factors that influence the ability of a woman with SLE to become pregnant, such as cytotoxic agents, other medications, advanced age and psychosocial effects of the disease, direct disease-related factors are believed to influence fertility. These include diminished ovarian reserve, menstrual irregularities (a function of disease activity) and the presence of antiphospholipid antibodies. The question of whether SLE intrinsically affects fertility, however, remains unanswered. In this review, we address known factors affecting fertility, assess current data regarding a direct impact of SLE on fertility and evaluate potential disease-related risk factors. We focus primarily on studies measuring anti-Müllerian hormone and antral follicle count, the most widely measured markers of ovarian reserve. Our goal is to provide information to rheumatologists faced with counselling patients with SLE regarding their fertility, family planning and options for assisted reproductive technologies, which now include fertility preservation through oocyte cryopreservation. BMJ Publishing Group 2022-12-13 /pmc/articles/PMC9748971/ /pubmed/36600642 http://dx.doi.org/10.1136/lupus-2022-000840 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Stamm, Bessie
Barbhaiya, Medha
Siegel, Caroline
Lieber, Sarah
Lockshin, Michael
Sammaritano, Lisa
Infertility in systemic lupus erythematosus: what rheumatologists need to know in a new age of assisted reproductive technology
title Infertility in systemic lupus erythematosus: what rheumatologists need to know in a new age of assisted reproductive technology
title_full Infertility in systemic lupus erythematosus: what rheumatologists need to know in a new age of assisted reproductive technology
title_fullStr Infertility in systemic lupus erythematosus: what rheumatologists need to know in a new age of assisted reproductive technology
title_full_unstemmed Infertility in systemic lupus erythematosus: what rheumatologists need to know in a new age of assisted reproductive technology
title_short Infertility in systemic lupus erythematosus: what rheumatologists need to know in a new age of assisted reproductive technology
title_sort infertility in systemic lupus erythematosus: what rheumatologists need to know in a new age of assisted reproductive technology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748971/
https://www.ncbi.nlm.nih.gov/pubmed/36600642
http://dx.doi.org/10.1136/lupus-2022-000840
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