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Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment
The environment plays a crucial role in the pathogenesis of various diseases, including rheumatic musculoskeletal diseases (RMDs). Chronic exposure to air pollution has been associated with a number of detrimental effects on the immune system, including direct activation of autoimmunity and autoanti...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748982/ https://www.ncbi.nlm.nih.gov/pubmed/36597981 http://dx.doi.org/10.1136/rmdopen-2022-002807 |
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author | Adami, Giovanni |
author_facet | Adami, Giovanni |
author_sort | Adami, Giovanni |
collection | PubMed |
description | The environment plays a crucial role in the pathogenesis of various diseases, including rheumatic musculoskeletal diseases (RMDs). Chronic exposure to air pollution has been associated with a number of detrimental effects on the immune system, including direct activation of autoimmunity and autoantibodies production. Rheumatoid arthritis (RA) is a paradigmatic example of the link between environmental stimuli and development of autoimmunity. Recent evidence has confirmed such association and provided further indication of the strict relationship between the lungs and the synovial tissue. Hard rock mining and chronic exposure to airborne fine particulate matter have been associated with higher risk of developing RA. In addition, new evidence showed a peculiar association between acute exposure to toxic inhalants and risk of RA flare. In conclusion, the environment is the straw that breaks the camel's back, unfortunately the “straws” are rapidly accumulating, and their burden is projected to increase accordingly. |
format | Online Article Text |
id | pubmed-9748982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-97489822022-12-15 Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment Adami, Giovanni RMD Open Rheumatoid Arthritis The environment plays a crucial role in the pathogenesis of various diseases, including rheumatic musculoskeletal diseases (RMDs). Chronic exposure to air pollution has been associated with a number of detrimental effects on the immune system, including direct activation of autoimmunity and autoantibodies production. Rheumatoid arthritis (RA) is a paradigmatic example of the link between environmental stimuli and development of autoimmunity. Recent evidence has confirmed such association and provided further indication of the strict relationship between the lungs and the synovial tissue. Hard rock mining and chronic exposure to airborne fine particulate matter have been associated with higher risk of developing RA. In addition, new evidence showed a peculiar association between acute exposure to toxic inhalants and risk of RA flare. In conclusion, the environment is the straw that breaks the camel's back, unfortunately the “straws” are rapidly accumulating, and their burden is projected to increase accordingly. BMJ Publishing Group 2022-12-12 /pmc/articles/PMC9748982/ /pubmed/36597981 http://dx.doi.org/10.1136/rmdopen-2022-002807 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Rheumatoid Arthritis Adami, Giovanni Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment |
title | Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment |
title_full | Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment |
title_fullStr | Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment |
title_full_unstemmed | Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment |
title_short | Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment |
title_sort | mining the pathogenesis of rheumatoid arthritis, the leading role of the environment |
topic | Rheumatoid Arthritis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748982/ https://www.ncbi.nlm.nih.gov/pubmed/36597981 http://dx.doi.org/10.1136/rmdopen-2022-002807 |
work_keys_str_mv | AT adamigiovanni miningthepathogenesisofrheumatoidarthritistheleadingroleoftheenvironment |