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Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment

The environment plays a crucial role in the pathogenesis of various diseases, including rheumatic musculoskeletal diseases (RMDs). Chronic exposure to air pollution has been associated with a number of detrimental effects on the immune system, including direct activation of autoimmunity and autoanti...

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Autor principal: Adami, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748982/
https://www.ncbi.nlm.nih.gov/pubmed/36597981
http://dx.doi.org/10.1136/rmdopen-2022-002807
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author Adami, Giovanni
author_facet Adami, Giovanni
author_sort Adami, Giovanni
collection PubMed
description The environment plays a crucial role in the pathogenesis of various diseases, including rheumatic musculoskeletal diseases (RMDs). Chronic exposure to air pollution has been associated with a number of detrimental effects on the immune system, including direct activation of autoimmunity and autoantibodies production. Rheumatoid arthritis (RA) is a paradigmatic example of the link between environmental stimuli and development of autoimmunity. Recent evidence has confirmed such association and provided further indication of the strict relationship between the lungs and the synovial tissue. Hard rock mining and chronic exposure to airborne fine particulate matter have been associated with higher risk of developing RA. In addition, new evidence showed a peculiar association between acute exposure to toxic inhalants and risk of RA flare. In conclusion, the environment is the straw that breaks the camel's back, unfortunately the “straws” are rapidly accumulating, and their burden is projected to increase accordingly.
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spelling pubmed-97489822022-12-15 Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment Adami, Giovanni RMD Open Rheumatoid Arthritis The environment plays a crucial role in the pathogenesis of various diseases, including rheumatic musculoskeletal diseases (RMDs). Chronic exposure to air pollution has been associated with a number of detrimental effects on the immune system, including direct activation of autoimmunity and autoantibodies production. Rheumatoid arthritis (RA) is a paradigmatic example of the link between environmental stimuli and development of autoimmunity. Recent evidence has confirmed such association and provided further indication of the strict relationship between the lungs and the synovial tissue. Hard rock mining and chronic exposure to airborne fine particulate matter have been associated with higher risk of developing RA. In addition, new evidence showed a peculiar association between acute exposure to toxic inhalants and risk of RA flare. In conclusion, the environment is the straw that breaks the camel's back, unfortunately the “straws” are rapidly accumulating, and their burden is projected to increase accordingly. BMJ Publishing Group 2022-12-12 /pmc/articles/PMC9748982/ /pubmed/36597981 http://dx.doi.org/10.1136/rmdopen-2022-002807 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Rheumatoid Arthritis
Adami, Giovanni
Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment
title Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment
title_full Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment
title_fullStr Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment
title_full_unstemmed Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment
title_short Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment
title_sort mining the pathogenesis of rheumatoid arthritis, the leading role of the environment
topic Rheumatoid Arthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748982/
https://www.ncbi.nlm.nih.gov/pubmed/36597981
http://dx.doi.org/10.1136/rmdopen-2022-002807
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