SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response

BACKGROUND: Understanding the role and potential therapeutic targeting of tumor-associated macrophages (TAMs) is crucial to developing new biomarkers and therapeutic strategies for cancer immunotherapies. The epigenetic reader SP140 has emerged as a master regulator of macrophage transcriptional pro...

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Detalles Bibliográficos
Autores principales: Tanagala, Kranthi Kiran Kishore, Morin-Baxter, Joshua, Carvajal, Richard, Cheema, Maryum, Dubey, Sunil, Nakagawa, Hiroshi, Yoon, Angela, Cheng, Yi-Shing L, Taylor, Alison, Nickerson, Jeffrey, Mintz, Akiva, Momen-Heravi, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Immunotherapy Biomarkers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748993/
https://www.ncbi.nlm.nih.gov/pubmed/36600652
http://dx.doi.org/10.1136/jitc-2022-005088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9748993/
https://www.ncbi.nlm.nih.gov/pubmed/36600652
http://dx.doi.org/10.1136/jitc-2022-005088

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