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A carbapenem antibiotic inhibiting a mammalian serine protease: structure of the acylaminoacyl peptidase–meropenem complex

The structure of porcine AAP (pAAP) in a covalently bound complex with meropenem was determined by cryo-EM to 2.1 Å resolution, showing the mammalian serine-protease inhibited by a carbapenem antibiotic. AAP is a modulator of the ubiquitin-proteasome degradation system and the site of a drug–drug in...

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Detalles Bibliográficos
Autores principales:	Kiss-Szemán, Anna J., Takács, Luca, Orgován, Zoltán, Stráner, Pál, Jákli, Imre, Schlosser, Gitta, Masiulis, Simonas, Harmat, Veronika, Menyhárd, Dóra K., Perczel, András
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749117/ https://www.ncbi.nlm.nih.gov/pubmed/36545146 http://dx.doi.org/10.1039/d2sc05520a

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