Longitudinal single-cell analysis of a patient receiving adoptive cell therapy reveals potential mechanisms of treatment failure

Adoptive cell therapy (ACT) using tumor infiltrating lymphocytes (TIL) is being studied in multiple tumor types. However, little is known about clonal cell expansion in vitro and persistence of the ACT product in vivo. We performed single-cell RNA and T-Cell Receptor (TCR) sequencing on serial blood...

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Detalles Bibliográficos
Autores principales: Qu, Rihao, Kluger, Yuval, Yang, Junchen, Zhao, Jun, Hafler, David A., Krause, Diane S., Bersenev, Alexey, Bosenberg, Marcus, Hurwitz, Michael, Lucca, Liliana, Kluger, Harriet M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749221/
https://www.ncbi.nlm.nih.gov/pubmed/36514045
http://dx.doi.org/10.1186/s12943-022-01688-5

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