Cargando…

SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex

Antisense oligonucleotide (ASO) therapy for neurological disease has been successful in clinical settings and its potential has generated hope for Alzheimer’s disease (AD). We previously described that ablating SNCA encoding for α-synuclein (αSyn) in a mouse model of AD was beneficial. Here, we soug...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brown, Jennifer L., Hart, Damyan W., Boyle, Gabriel E., Brown, Taylor G., LaCroix, Michael, Baraibar, Andrés M., Pelzel, Ross, Kim, Minwoo, Sherman, Mathew A., Boes, Samuel, Sung, Michelle, Cole, Tracy, Lee, Michael K., Araque, Alfonso, Lesné, Sylvain E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749314/ https://www.ncbi.nlm.nih.gov/pubmed/36517890 http://dx.doi.org/10.1186/s40478-022-01480-y

Ejemplares similares

Network Analysis Implicates Alpha-Synuclein (Snca) in the Regulation of Ovariectomy-Induced Bone Loss
por: Calabrese, Gina, et al.
Publicado: (2016)

The Impact of SNCA Variations and Its Product Alpha-Synuclein on Non-Motor Features of Parkinson’s Disease
por: Magistrelli, Luca, et al.
Publicado: (2021)

Linking the phenotype of SNCA Triplication with PET-MRI imaging pattern and alpha-synuclein CSF seeding
por: Wurster, Isabel, et al.
Publicado: (2022)

Alpha‐synuclein mRNA isoform formation and translation affected by polymorphism in the human SNCA 3ʹUTR
por: Barrie, Elizabeth S., et al.
Publicado: (2018)

Genetic Variants of the α-Synuclein Gene SNCA Are Associated with Multiple System Atrophy
por: Al-Chalabi, Ammar, et al.
Publicado: (2009)

Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson’s disease patients
por: Kang, Wenyan, et al.
Publicado: (2016)

Snca-GFP Knock-In Mice Allows Tracking the Endogenous α-Synuclein in Action
por: Er, Safak
Publicado: (2021)

A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity
por: Suresh, S. N., et al.
Publicado: (2017)

Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease
por: Guhathakurta, Subhrangshu, et al.
Publicado: (2021)

New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy
por: Yang, Yang, et al.
Publicado: (2023)

Regulation of Αlpha-Synuclein Gene (SNCA) by Epigenetic Modifier TET1 in Parkinson Disease
por: Guhathakurta, Subhrangshu, et al.
Publicado: (2022)

Alpha‐synuclein dynamics in induced pluripotent stem cell‐derived dopaminergic neurons from a Parkinson’s disease patient (PARK4) with SNCA triplication
por: Fukusumi, Hayato, et al.
Publicado: (2021)

The SNCA-Rep1 Polymorphic Locus: Association with the Risk of Parkinson’s Disease and SNCA Gene Methylation
por: Iakovenko, E. V., et al.
Publicado: (2020)

Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk
por: Kayed, Rakez, et al.
Publicado: (2020)

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models
por: Prieto Huarcaya, Susy, et al.
Publicado: (2022)

Alpha-Synuclein Is a Cellular Ferrireductase
por: Davies, Paul, et al.
Publicado: (2011)

Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human α-synuclein in transgenic mouse brain
por: Cronin, Kenneth D., et al.
Publicado: (2009)

Kinetics of alpha-synuclein depletion in three brain regions following conditional pan-neuronal inactivation of the encoding gene (Snca) by tamoxifen-induced Cre-recombination in adult mice
por: Chaprov, Kirill D., et al.
Publicado: (2021)

Correction: Alpha-Synuclein Is a Cellular Ferrireductase
por: Davies, Paul, et al.
Publicado: (2011)

SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress
por: Byers, Blake, et al.
Publicado: (2011)

A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expression
por: Ninkina, Natalia, et al.
Publicado: (2015)

Gastrointestinal Immunity and Alpha-Synuclein
por: Barbut, Denise, et al.
Publicado: (2019)

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
por: Dening, Yanina, et al.
Publicado: (2022)

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies
por: Okita, Yuho, et al.
Publicado: (2017)

Piperine promotes autophagy flux by P2RX4 activation in SNCA/α-synuclein-induced Parkinson disease model
por: Li, Ruolin, et al.
Publicado: (2021)

α‐Synuclein antisense transcript SNCA‐AS1 regulates synapses‐ and aging‐related genes suggesting its implication in Parkinson's disease
por: Rey, Federica, et al.
Publicado: (2021)

The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease
por: Lau, Heather H. C., et al.
Publicado: (2023)

SNCA-AS1 in aging and Parkinson’s disease
por: Carelli, Stephana, et al.
Publicado: (2022)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells
por: Oliveira, L M A, et al.
Publicado: (2015)

Generation of two human induced pluripotent stem cell lines (iPSCs) with mutations of the α-synuclein (SNCA) gene associated with Parkinson’s disease; the A53T mutation (LCSBi003) and a triplication of the SNCA gene (LCSBi007)
por: Novak, Gabriela, et al.
Publicado: (2021)

Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut
por: Nimmo, Jacqui T., et al.
Publicado: (2021)

Snca-GFP Knock-In Mice Reflect Patterns of Endogenous Expression and Pathological Seeding
por: Caputo, Anna, et al.
Publicado: (2020)

CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in huntington’s disease
por: Yu, Dahyun, et al.
Publicado: (2022)

Neuronal SNCA transcription during Lewy body formation
por: Kon, Tomoya, et al.
Publicado: (2023)

Correction to: CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington’s disease
por: Yu, Dahyun, et al.
Publicado: (2022)

Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice
por: Okuda, Shinya, et al.
Publicado: (2022)

Evaluation of the Role of SNCA Variants in Survival without Neurological Disease
por: Heckman, Michael G., et al.
Publicado: (2012)

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum
por: Miraglia, Fabiana, et al.
Publicado: (2020)

Alpha-Synuclein Aggregation in Parkinson's Disease
por: Srinivasan, E., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_h7qb6jv093v6ih8j9so9u0r1h2