The P681H Mutation in the Spike Glycoprotein of the Alpha Variant of SARS-CoV-2 Escapes IFITM Restriction and Is Necessary for Type I Interferon Resistance

The appearance of new dominant variants of concern (VOC) of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) threatens the global response to the coronavirus disease 2019 (COVID-19) pandemic. Of these, the alpha variant (also known as B.1.1.7), which appeared initially in the United...

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Detalles Bibliográficos
Autores principales: Lista, Maria Jose, Winstone, Helena, Wilson, Harry D., Dyer, Adam, Pickering, Suzanne, Galao, Rui Pedro, De Lorenzo, Giuditta, Cowton, Vanessa M., Furnon, Wilhelm, Suarez, Nicolas, Orton, Richard, Palmarini, Massimo, Patel, Arvind H., Snell, Luke, Nebbia, Gaia, Swanson, Chad, Neil, Stuart J. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Pathogenesis and Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749455/
https://www.ncbi.nlm.nih.gov/pubmed/36350154
http://dx.doi.org/10.1128/jvi.01250-22

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