In vitro ion channel profile and ex vivo cardiac electrophysiology properties of the R(-) and S(+) enantiomers of hydroxychloroquine

Hydroxychloroquine (HCQ) is a derivative of the antimalaria drug chloroquine primarily prescribed for autoimmune diseases. Recent attempts to repurpose HCQ in the treatment of corona virus disease 2019 has raised concerns because of its propensity to prolong the QT-segment on the electrocardiogram,...

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Detalles Bibliográficos
Autores principales: Ballet, Véronique, Bohme, G. Andrees, Brohan, Eric, Boukaiba, Rachid, Chambard, Jean-Marie, Angouillant-Boniface, Odile, Carriot, Thierry, Chantoiseau, Céline, Fouconnier, Sophie, Houtmann, Sylvie, Prévost, Céline, Schombert, Brigitte, Schio, Laurent, Partiseti, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749463/
https://www.ncbi.nlm.nih.gov/pubmed/34863995
http://dx.doi.org/10.1016/j.ejphar.2021.174670

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