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An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review

Since the last century, methicillin-resistant Staphylococcus aureus (MRSA) bacteremia has become a major global and public health concern not only in terms of morbidity and mortality but also the duration of hospital stay, healthcare cost, and antimicrobial choices. Especially alarming is the growin...

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Autores principales: Mahjabeen, Fatema, Saha, Utsow, Mostafa, Mayesha N, Siddique, Farzana, Ahsan, Eram, Fathma, Sawsan, Tasnim, Anika, Rahman, Tasnim, Faruq, Ridwan, Sakibuzzaman, Md, Dilnaz, Fahmida, Ashraf, Adrita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749567/
https://www.ncbi.nlm.nih.gov/pubmed/36523711
http://dx.doi.org/10.7759/cureus.31486
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author Mahjabeen, Fatema
Saha, Utsow
Mostafa, Mayesha N
Siddique, Farzana
Ahsan, Eram
Fathma, Sawsan
Tasnim, Anika
Rahman, Tasnim
Faruq, Ridwan
Sakibuzzaman, Md
Dilnaz, Fahmida
Ashraf, Adrita
author_facet Mahjabeen, Fatema
Saha, Utsow
Mostafa, Mayesha N
Siddique, Farzana
Ahsan, Eram
Fathma, Sawsan
Tasnim, Anika
Rahman, Tasnim
Faruq, Ridwan
Sakibuzzaman, Md
Dilnaz, Fahmida
Ashraf, Adrita
author_sort Mahjabeen, Fatema
collection PubMed
description Since the last century, methicillin-resistant Staphylococcus aureus (MRSA) bacteremia has become a major global and public health concern not only in terms of morbidity and mortality but also the duration of hospital stay, healthcare cost, and antimicrobial choices. Especially alarming is the growing antimicrobial resistance due to their misuse and overuse, which has led the world to be exhausted of its effective antibiotic resources. In this review article, we sought to figure out the most efficacious antimicrobial agents to treat MRSA-related bloodstream infections. We compared the data from reviewing reports from 2017 to 2022 and summarized their comparative efficacy and cost-effectiveness. Although we focused on vancomycin and daptomycin, which are the current Infectious Disease Society Of America (IDSA)-recommended antibiotics for MRSA bacteremia treatment, a deep dive into the newer agents revealed better efficacy and treatment outcome in the combination of ceftaroline (β-lactam) with daptomycin compared to traditional standard monotherapy (vancomycin/daptomycin monotherapy). Also, the IDSA recommended high-dose daptomycin (8-10 mg/kg) therapy for MRSA bacteremia treatment to be more effective in cases with vancomycin-reduced susceptibility. Moreover, we did not find any trial or study describing the use of ceftaroline as a monotherapy to compare its efficacy in MRSA bacteremia with the current standard therapy. The upshot is that we need more large-scale clinical trials exploring in-depth effectiveness and adverse effects to decide on newer agents like β-lactams to use as routine therapy for MRSA bacteremia.
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spelling pubmed-97495672022-12-14 An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review Mahjabeen, Fatema Saha, Utsow Mostafa, Mayesha N Siddique, Farzana Ahsan, Eram Fathma, Sawsan Tasnim, Anika Rahman, Tasnim Faruq, Ridwan Sakibuzzaman, Md Dilnaz, Fahmida Ashraf, Adrita Cureus Internal Medicine Since the last century, methicillin-resistant Staphylococcus aureus (MRSA) bacteremia has become a major global and public health concern not only in terms of morbidity and mortality but also the duration of hospital stay, healthcare cost, and antimicrobial choices. Especially alarming is the growing antimicrobial resistance due to their misuse and overuse, which has led the world to be exhausted of its effective antibiotic resources. In this review article, we sought to figure out the most efficacious antimicrobial agents to treat MRSA-related bloodstream infections. We compared the data from reviewing reports from 2017 to 2022 and summarized their comparative efficacy and cost-effectiveness. Although we focused on vancomycin and daptomycin, which are the current Infectious Disease Society Of America (IDSA)-recommended antibiotics for MRSA bacteremia treatment, a deep dive into the newer agents revealed better efficacy and treatment outcome in the combination of ceftaroline (β-lactam) with daptomycin compared to traditional standard monotherapy (vancomycin/daptomycin monotherapy). Also, the IDSA recommended high-dose daptomycin (8-10 mg/kg) therapy for MRSA bacteremia treatment to be more effective in cases with vancomycin-reduced susceptibility. Moreover, we did not find any trial or study describing the use of ceftaroline as a monotherapy to compare its efficacy in MRSA bacteremia with the current standard therapy. The upshot is that we need more large-scale clinical trials exploring in-depth effectiveness and adverse effects to decide on newer agents like β-lactams to use as routine therapy for MRSA bacteremia. Cureus 2022-11-14 /pmc/articles/PMC9749567/ /pubmed/36523711 http://dx.doi.org/10.7759/cureus.31486 Text en Copyright © 2022, Mahjabeen et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Mahjabeen, Fatema
Saha, Utsow
Mostafa, Mayesha N
Siddique, Farzana
Ahsan, Eram
Fathma, Sawsan
Tasnim, Anika
Rahman, Tasnim
Faruq, Ridwan
Sakibuzzaman, Md
Dilnaz, Fahmida
Ashraf, Adrita
An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review
title An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review
title_full An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review
title_fullStr An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review
title_full_unstemmed An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review
title_short An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review
title_sort update on treatment options for methicillin-resistant staphylococcus aureus (mrsa) bacteremia: a systematic review
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749567/
https://www.ncbi.nlm.nih.gov/pubmed/36523711
http://dx.doi.org/10.7759/cureus.31486
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