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An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review
Since the last century, methicillin-resistant Staphylococcus aureus (MRSA) bacteremia has become a major global and public health concern not only in terms of morbidity and mortality but also the duration of hospital stay, healthcare cost, and antimicrobial choices. Especially alarming is the growin...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749567/ https://www.ncbi.nlm.nih.gov/pubmed/36523711 http://dx.doi.org/10.7759/cureus.31486 |
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author | Mahjabeen, Fatema Saha, Utsow Mostafa, Mayesha N Siddique, Farzana Ahsan, Eram Fathma, Sawsan Tasnim, Anika Rahman, Tasnim Faruq, Ridwan Sakibuzzaman, Md Dilnaz, Fahmida Ashraf, Adrita |
author_facet | Mahjabeen, Fatema Saha, Utsow Mostafa, Mayesha N Siddique, Farzana Ahsan, Eram Fathma, Sawsan Tasnim, Anika Rahman, Tasnim Faruq, Ridwan Sakibuzzaman, Md Dilnaz, Fahmida Ashraf, Adrita |
author_sort | Mahjabeen, Fatema |
collection | PubMed |
description | Since the last century, methicillin-resistant Staphylococcus aureus (MRSA) bacteremia has become a major global and public health concern not only in terms of morbidity and mortality but also the duration of hospital stay, healthcare cost, and antimicrobial choices. Especially alarming is the growing antimicrobial resistance due to their misuse and overuse, which has led the world to be exhausted of its effective antibiotic resources. In this review article, we sought to figure out the most efficacious antimicrobial agents to treat MRSA-related bloodstream infections. We compared the data from reviewing reports from 2017 to 2022 and summarized their comparative efficacy and cost-effectiveness. Although we focused on vancomycin and daptomycin, which are the current Infectious Disease Society Of America (IDSA)-recommended antibiotics for MRSA bacteremia treatment, a deep dive into the newer agents revealed better efficacy and treatment outcome in the combination of ceftaroline (β-lactam) with daptomycin compared to traditional standard monotherapy (vancomycin/daptomycin monotherapy). Also, the IDSA recommended high-dose daptomycin (8-10 mg/kg) therapy for MRSA bacteremia treatment to be more effective in cases with vancomycin-reduced susceptibility. Moreover, we did not find any trial or study describing the use of ceftaroline as a monotherapy to compare its efficacy in MRSA bacteremia with the current standard therapy. The upshot is that we need more large-scale clinical trials exploring in-depth effectiveness and adverse effects to decide on newer agents like β-lactams to use as routine therapy for MRSA bacteremia. |
format | Online Article Text |
id | pubmed-9749567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-97495672022-12-14 An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review Mahjabeen, Fatema Saha, Utsow Mostafa, Mayesha N Siddique, Farzana Ahsan, Eram Fathma, Sawsan Tasnim, Anika Rahman, Tasnim Faruq, Ridwan Sakibuzzaman, Md Dilnaz, Fahmida Ashraf, Adrita Cureus Internal Medicine Since the last century, methicillin-resistant Staphylococcus aureus (MRSA) bacteremia has become a major global and public health concern not only in terms of morbidity and mortality but also the duration of hospital stay, healthcare cost, and antimicrobial choices. Especially alarming is the growing antimicrobial resistance due to their misuse and overuse, which has led the world to be exhausted of its effective antibiotic resources. In this review article, we sought to figure out the most efficacious antimicrobial agents to treat MRSA-related bloodstream infections. We compared the data from reviewing reports from 2017 to 2022 and summarized their comparative efficacy and cost-effectiveness. Although we focused on vancomycin and daptomycin, which are the current Infectious Disease Society Of America (IDSA)-recommended antibiotics for MRSA bacteremia treatment, a deep dive into the newer agents revealed better efficacy and treatment outcome in the combination of ceftaroline (β-lactam) with daptomycin compared to traditional standard monotherapy (vancomycin/daptomycin monotherapy). Also, the IDSA recommended high-dose daptomycin (8-10 mg/kg) therapy for MRSA bacteremia treatment to be more effective in cases with vancomycin-reduced susceptibility. Moreover, we did not find any trial or study describing the use of ceftaroline as a monotherapy to compare its efficacy in MRSA bacteremia with the current standard therapy. The upshot is that we need more large-scale clinical trials exploring in-depth effectiveness and adverse effects to decide on newer agents like β-lactams to use as routine therapy for MRSA bacteremia. Cureus 2022-11-14 /pmc/articles/PMC9749567/ /pubmed/36523711 http://dx.doi.org/10.7759/cureus.31486 Text en Copyright © 2022, Mahjabeen et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Mahjabeen, Fatema Saha, Utsow Mostafa, Mayesha N Siddique, Farzana Ahsan, Eram Fathma, Sawsan Tasnim, Anika Rahman, Tasnim Faruq, Ridwan Sakibuzzaman, Md Dilnaz, Fahmida Ashraf, Adrita An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review |
title | An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review |
title_full | An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review |
title_fullStr | An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review |
title_full_unstemmed | An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review |
title_short | An Update on Treatment Options for Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review |
title_sort | update on treatment options for methicillin-resistant staphylococcus aureus (mrsa) bacteremia: a systematic review |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749567/ https://www.ncbi.nlm.nih.gov/pubmed/36523711 http://dx.doi.org/10.7759/cureus.31486 |
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