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Elevated level of creatine phosphokinase in newborn: Clinical significance and association with congenital muscle diseases

OBJECTIVES: To establish the normal Creatine phosphokinase (CPK) range in newborns of all 3 modes of delivery and prove that high CPK level in neonates is not specific a indicator for muscular pathology. METHODS: This is a prospective cohort study that is conducted in King Abdulaziz Medical City and...

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Autores principales: Al-twaijri, Waleed A., Al-saif, Saif A., Al-fehaid, Ghina I., Al-qirnas, Muhannad Q., Masuadi, Emad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Riyadh : Armed Forces Hospital 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749574/
https://www.ncbi.nlm.nih.gov/pubmed/36252976
http://dx.doi.org/10.17712/nsj.2022.4.20220051
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author Al-twaijri, Waleed A.
Al-saif, Saif A.
Al-fehaid, Ghina I.
Al-qirnas, Muhannad Q.
Masuadi, Emad M.
author_facet Al-twaijri, Waleed A.
Al-saif, Saif A.
Al-fehaid, Ghina I.
Al-qirnas, Muhannad Q.
Masuadi, Emad M.
author_sort Al-twaijri, Waleed A.
collection PubMed
description OBJECTIVES: To establish the normal Creatine phosphokinase (CPK) range in newborns of all 3 modes of delivery and prove that high CPK level in neonates is not specific a indicator for muscular pathology. METHODS: This is a prospective cohort study that is conducted in King Abdulaziz Medical City and King Abdullah Specialized Children Hospital in Riyadh and included 504 term neonates who were born between March 2021 and August 2021. Two hundred and fifty three were males and 251 were females. Data and consents were managed and collected using 2 coordinators. RESULTS: Duration of the second stage of labor, age on the first CPK test and fetal gestational age were significantly correlated with CPK values (r=0.197, r=-0.234, r=0.274, respectively). The normal ranges for each delivery type were 334 U/L-2667U/L in normal spontaneous vaginal delivery, 265U/L-1182U/L in elective cesarean section, and 223U/L-3082 U/L in emergency cesarean section. CONCLUSION: The CPK was elevated in all neonates in all 3 modes of deliveries. An elevated levels of CPK in neonates is not a specific indicator for any congenital muscular pathology.
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spelling pubmed-97495742023-01-04 Elevated level of creatine phosphokinase in newborn: Clinical significance and association with congenital muscle diseases Al-twaijri, Waleed A. Al-saif, Saif A. Al-fehaid, Ghina I. Al-qirnas, Muhannad Q. Masuadi, Emad M. Neurosciences (Riyadh) Original Article OBJECTIVES: To establish the normal Creatine phosphokinase (CPK) range in newborns of all 3 modes of delivery and prove that high CPK level in neonates is not specific a indicator for muscular pathology. METHODS: This is a prospective cohort study that is conducted in King Abdulaziz Medical City and King Abdullah Specialized Children Hospital in Riyadh and included 504 term neonates who were born between March 2021 and August 2021. Two hundred and fifty three were males and 251 were females. Data and consents were managed and collected using 2 coordinators. RESULTS: Duration of the second stage of labor, age on the first CPK test and fetal gestational age were significantly correlated with CPK values (r=0.197, r=-0.234, r=0.274, respectively). The normal ranges for each delivery type were 334 U/L-2667U/L in normal spontaneous vaginal delivery, 265U/L-1182U/L in elective cesarean section, and 223U/L-3082 U/L in emergency cesarean section. CONCLUSION: The CPK was elevated in all neonates in all 3 modes of deliveries. An elevated levels of CPK in neonates is not a specific indicator for any congenital muscular pathology. Riyadh : Armed Forces Hospital 2022-10 /pmc/articles/PMC9749574/ /pubmed/36252976 http://dx.doi.org/10.17712/nsj.2022.4.20220051 Text en Copyright: © Neurosciences https://creativecommons.org/licenses/by-nc/3.0/Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.
spellingShingle Original Article
Al-twaijri, Waleed A.
Al-saif, Saif A.
Al-fehaid, Ghina I.
Al-qirnas, Muhannad Q.
Masuadi, Emad M.
Elevated level of creatine phosphokinase in newborn: Clinical significance and association with congenital muscle diseases
title Elevated level of creatine phosphokinase in newborn: Clinical significance and association with congenital muscle diseases
title_full Elevated level of creatine phosphokinase in newborn: Clinical significance and association with congenital muscle diseases
title_fullStr Elevated level of creatine phosphokinase in newborn: Clinical significance and association with congenital muscle diseases
title_full_unstemmed Elevated level of creatine phosphokinase in newborn: Clinical significance and association with congenital muscle diseases
title_short Elevated level of creatine phosphokinase in newborn: Clinical significance and association with congenital muscle diseases
title_sort elevated level of creatine phosphokinase in newborn: clinical significance and association with congenital muscle diseases
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749574/
https://www.ncbi.nlm.nih.gov/pubmed/36252976
http://dx.doi.org/10.17712/nsj.2022.4.20220051
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