A Convenient One-Pot Synthesis of Bis(indolyl)methane Derivatives and Evaluation of Their Nematicidal Activity against the Root Knot Nematode Meloidogyne incognita

Seven arylbis(indolyl)methanes were synthesized by electrophilic substitution reaction of aromatic aldehydes on indole using glacial acetic acid as catalyst in aqueous media under ultrasonic irradiation. The synthesized bis-indole derivatives were characterized using elemental analysis, (1)H and (13...

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Autores principales: Rani, M., Utreja, D., Dhillon, N. K., Kaur, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749629/
http://dx.doi.org/10.1134/S1070428022100219
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author Rani, M.
Utreja, D.
Dhillon, N. K.
Kaur, K.
author_facet Rani, M.
Utreja, D.
Dhillon, N. K.
Kaur, K.
author_sort Rani, M.
collection PubMed
description Seven arylbis(indolyl)methanes were synthesized by electrophilic substitution reaction of aromatic aldehydes on indole using glacial acetic acid as catalyst in aqueous media under ultrasonic irradiation. The synthesized bis-indole derivatives were characterized using elemental analysis, (1)H and (13)C NMR, FT-IR spectroscopy, and mass spectrometry and were screened for their nematicidal activity against the root knot nematode Meloidogyne incognita. The efficiency of the synthesized compounds was evaluated in vitro by egg hatching and mortality tests. All tested compounds showed significant nematicidal potential, and the nitro substituted derivative, 3,3′-[(4-nitrophenyl)methylene]di(1H-indole), exhibited the highest activity.
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spelling pubmed-97496292022-12-14 A Convenient One-Pot Synthesis of Bis(indolyl)methane Derivatives and Evaluation of Their Nematicidal Activity against the Root Knot Nematode Meloidogyne incognita Rani, M. Utreja, D. Dhillon, N. K. Kaur, K. Russ J Org Chem Article Seven arylbis(indolyl)methanes were synthesized by electrophilic substitution reaction of aromatic aldehydes on indole using glacial acetic acid as catalyst in aqueous media under ultrasonic irradiation. The synthesized bis-indole derivatives were characterized using elemental analysis, (1)H and (13)C NMR, FT-IR spectroscopy, and mass spectrometry and were screened for their nematicidal activity against the root knot nematode Meloidogyne incognita. The efficiency of the synthesized compounds was evaluated in vitro by egg hatching and mortality tests. All tested compounds showed significant nematicidal potential, and the nitro substituted derivative, 3,3′-[(4-nitrophenyl)methylene]di(1H-indole), exhibited the highest activity. Pleiades Publishing 2022-12-14 2022 /pmc/articles/PMC9749629/ http://dx.doi.org/10.1134/S1070428022100219 Text en © Pleiades Publishing, Ltd. 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Rani, M.
Utreja, D.
Dhillon, N. K.
Kaur, K.
A Convenient One-Pot Synthesis of Bis(indolyl)methane Derivatives and Evaluation of Their Nematicidal Activity against the Root Knot Nematode Meloidogyne incognita
title A Convenient One-Pot Synthesis of Bis(indolyl)methane Derivatives and Evaluation of Their Nematicidal Activity against the Root Knot Nematode Meloidogyne incognita
title_full A Convenient One-Pot Synthesis of Bis(indolyl)methane Derivatives and Evaluation of Their Nematicidal Activity against the Root Knot Nematode Meloidogyne incognita
title_fullStr A Convenient One-Pot Synthesis of Bis(indolyl)methane Derivatives and Evaluation of Their Nematicidal Activity against the Root Knot Nematode Meloidogyne incognita
title_full_unstemmed A Convenient One-Pot Synthesis of Bis(indolyl)methane Derivatives and Evaluation of Their Nematicidal Activity against the Root Knot Nematode Meloidogyne incognita
title_short A Convenient One-Pot Synthesis of Bis(indolyl)methane Derivatives and Evaluation of Their Nematicidal Activity against the Root Knot Nematode Meloidogyne incognita
title_sort convenient one-pot synthesis of bis(indolyl)methane derivatives and evaluation of their nematicidal activity against the root knot nematode meloidogyne incognita
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749629/
http://dx.doi.org/10.1134/S1070428022100219
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