Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression

This review is focused on polyprenyl phosphatis (PPFs) (phosphorilated polyprenols), a unique class of natural compounds with a wide spectrum of biological activity. The main emphasis is put on their antiviral properties that were studied in numerous in vitro and in vivo experiments. The results for...

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Detalles Bibliográficos
Autores principales: Sanin, A. V., Pronin, A. V., Narovlyanskiy, A. N., Ozherelkov, S. V., Sedov, A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749632/
http://dx.doi.org/10.1134/S207908642206007X
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author Sanin, A. V.
Pronin, A. V.
Narovlyanskiy, A. N.
Ozherelkov, S. V.
Sedov, A. M.
author_facet Sanin, A. V.
Pronin, A. V.
Narovlyanskiy, A. N.
Ozherelkov, S. V.
Sedov, A. M.
author_sort Sanin, A. V.
collection PubMed
description This review is focused on polyprenyl phosphatis (PPFs) (phosphorilated polyprenols), a unique class of natural compounds with a wide spectrum of biological activity. The main emphasis is put on their antiviral properties that were studied in numerous in vitro and in vivo experiments. The results formed the basis for the development of new drugs containing PPFs as the active substance. These drugs, due to their high efficiency and harmlessness, are widely used in veterinary practice in the treatment of viral diseases of both small domestic and agricultural animals. Also, the world’s first PPF-based drug is registered in Russia, and it can be used as part of a comprehensive therapy of chronic recurrent genital infection caused by the herpes simplex virus.
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spelling pubmed-97496322022-12-14 Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression Sanin, A. V. Pronin, A. V. Narovlyanskiy, A. N. Ozherelkov, S. V. Sedov, A. M. Biol Bull Rev Article This review is focused on polyprenyl phosphatis (PPFs) (phosphorilated polyprenols), a unique class of natural compounds with a wide spectrum of biological activity. The main emphasis is put on their antiviral properties that were studied in numerous in vitro and in vivo experiments. The results formed the basis for the development of new drugs containing PPFs as the active substance. These drugs, due to their high efficiency and harmlessness, are widely used in veterinary practice in the treatment of viral diseases of both small domestic and agricultural animals. Also, the world’s first PPF-based drug is registered in Russia, and it can be used as part of a comprehensive therapy of chronic recurrent genital infection caused by the herpes simplex virus. Pleiades Publishing 2022-12-14 2022 /pmc/articles/PMC9749632/ http://dx.doi.org/10.1134/S207908642206007X Text en © Pleiades Publishing, Ltd. 2022, ISSN 2079-0864, Biology Bulletin Reviews, 2022, Vol. 12, No. 6, pp. 609–624. © Pleiades Publishing, Ltd., 2022.Russian Text © The Author(s), 2022, published in Uspekhi Sovremennoi Biologii, 2022, Vol. 142, No. 3, pp. 268–285. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Sanin, A. V.
Pronin, A. V.
Narovlyanskiy, A. N.
Ozherelkov, S. V.
Sedov, A. M.
Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression
title Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression
title_full Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression
title_fullStr Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression
title_full_unstemmed Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression
title_short Phosphorilated Polyprenols as Universal Agents of Viral Reproduction Suppression
title_sort phosphorilated polyprenols as universal agents of viral reproduction suppression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749632/
http://dx.doi.org/10.1134/S207908642206007X
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