False-positive Xpert(®) Xpress SARS-CoV-2 assay in an emergency room and trauma center: A retrospective chart review study

OBJECTIVES: To review reports false-positive Xpert results in an emergency room and trauma center. METHODS: Patients’ data with false-positive Xpert results from November 2020 to February 2022 at Pusan National University Hospital, Busan, Republic of Korea, were extracted from the electronic medical...

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Detalles Bibliográficos
Autores principales: Kim, Hyerim, Jeon, Soeun, Lee, Sun Hack, Ri, Hyun-Su, Lee, Hyeon-Jeong, Hong, Jeong-Min, Paek, Sung In
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Saudi Medical Journal 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749665/
https://www.ncbi.nlm.nih.gov/pubmed/35964955
http://dx.doi.org/10.15537/smj.2022.43.8.20220317
Descripción
Sumario:OBJECTIVES: To review reports false-positive Xpert results in an emergency room and trauma center. METHODS: Patients’ data with false-positive Xpert results from November 2020 to February 2022 at Pusan National University Hospital, Busan, Republic of Korea, were extracted from the electronic medical records. RESULTS: The positive predictive value of Xpert was 40%. Of the 12 patients with false-positive results, 5 (41.7%) were re-positives (such as, patients recovered from coronavirus disease-19 [COVID-19]), and 4 (33.3%) had head or facial trauma. Two out of 4 head or facial trauma cases had documented sample contamination with blood. CONCLUSION: We found a high incidence of false-positive Xpert results among patients who recovered from COVID-19 and those with head or facial injury. Careful history taking for COVID-19 and physical examination of the sample collection site is essential before Xpert analysis.

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