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Clustered Mendelian randomization analyses identify distinct and opposing pathways in the association between genetically influenced insulin-like growth factor-1 and type 2 diabetes mellitus

BACKGROUND: There is inconsistent evidence for the causal role of serum insulin-like growth factor-1 (IGF-1) concentration in the pathogenesis of human age-related diseases such as type 2 diabetes (T2D). Here, we investigated the association between IGF-1 and T2D using (clustered) Mendelian randomiz...

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Detalles Bibliográficos
Autores principales:	Wang, Wenyi, Tesfay, Ephrem Baraki, van Klinken, Jan Bert, Willems van Dijk, Ko, Bartke, Andrzej, van Heemst, Diana, Noordam, Raymond
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Diabetes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749721/ https://www.ncbi.nlm.nih.gov/pubmed/35656699 http://dx.doi.org/10.1093/ije/dyac119

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