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Differences in gut microbial fructoselysine degradation activity between breast-fed and formula-fed infants
The Amadori product fructoselysine is formed upon heating of food products and is abundantly present in infant formula while being almost absent in breast milk. The human gut microbiota can degrade fructoselysine for which interindividual differences have been described for adults. The aim of this s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749803/ https://www.ncbi.nlm.nih.gov/pubmed/36442156 http://dx.doi.org/10.1093/femsec/fiac145 |
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author | van Dongen, Katja C W Ioannou, Athanasia Wesseling, Sebastiaan Beekmann, Karsten Belzer, Clara |
author_facet | van Dongen, Katja C W Ioannou, Athanasia Wesseling, Sebastiaan Beekmann, Karsten Belzer, Clara |
author_sort | van Dongen, Katja C W |
collection | PubMed |
description | The Amadori product fructoselysine is formed upon heating of food products and is abundantly present in infant formula while being almost absent in breast milk. The human gut microbiota can degrade fructoselysine for which interindividual differences have been described for adults. The aim of this study is to compare functional differences in microbial fructoselysine degradation between breast-fed and formula-fed infants, in view of their different diets and resulting different fructoselysine exposures. First, a publicly available metagenomic dataset with metagenome-assembled genomes (MAGs) from infant fecal samples was analyzed and showed that query genes involved in fructoselysine degradation (frlD/yhfQ) were abundantly present in multiple bacterial taxa in the fecal samples, with a higher prevalence in the formula-fed infants. Next, fecal samples collected from exclusively breast-fed and formula-fed infants were anaerobically incubated with fructoselysine. Both groups degraded fructoselysine, however the fructoselysine degradation activity was significantly higher by fecal samples from formula-fed infants. Overall, this study provides evidence that infant formula feeding, leading to increased dietary fructoselysine exposure, seems to result in an increased fructoselysine degradation activity in the gut microbiota of infants. This indicates that the infant gut microbiota adapts towards dietary fructoselysine exposure. |
format | Online Article Text |
id | pubmed-9749803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-97498032022-12-15 Differences in gut microbial fructoselysine degradation activity between breast-fed and formula-fed infants van Dongen, Katja C W Ioannou, Athanasia Wesseling, Sebastiaan Beekmann, Karsten Belzer, Clara FEMS Microbiol Ecol Research Article The Amadori product fructoselysine is formed upon heating of food products and is abundantly present in infant formula while being almost absent in breast milk. The human gut microbiota can degrade fructoselysine for which interindividual differences have been described for adults. The aim of this study is to compare functional differences in microbial fructoselysine degradation between breast-fed and formula-fed infants, in view of their different diets and resulting different fructoselysine exposures. First, a publicly available metagenomic dataset with metagenome-assembled genomes (MAGs) from infant fecal samples was analyzed and showed that query genes involved in fructoselysine degradation (frlD/yhfQ) were abundantly present in multiple bacterial taxa in the fecal samples, with a higher prevalence in the formula-fed infants. Next, fecal samples collected from exclusively breast-fed and formula-fed infants were anaerobically incubated with fructoselysine. Both groups degraded fructoselysine, however the fructoselysine degradation activity was significantly higher by fecal samples from formula-fed infants. Overall, this study provides evidence that infant formula feeding, leading to increased dietary fructoselysine exposure, seems to result in an increased fructoselysine degradation activity in the gut microbiota of infants. This indicates that the infant gut microbiota adapts towards dietary fructoselysine exposure. Oxford University Press 2022-11-28 /pmc/articles/PMC9749803/ /pubmed/36442156 http://dx.doi.org/10.1093/femsec/fiac145 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of FEMS. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article van Dongen, Katja C W Ioannou, Athanasia Wesseling, Sebastiaan Beekmann, Karsten Belzer, Clara Differences in gut microbial fructoselysine degradation activity between breast-fed and formula-fed infants |
title | Differences in gut microbial fructoselysine degradation activity between breast-fed and formula-fed infants |
title_full | Differences in gut microbial fructoselysine degradation activity between breast-fed and formula-fed infants |
title_fullStr | Differences in gut microbial fructoselysine degradation activity between breast-fed and formula-fed infants |
title_full_unstemmed | Differences in gut microbial fructoselysine degradation activity between breast-fed and formula-fed infants |
title_short | Differences in gut microbial fructoselysine degradation activity between breast-fed and formula-fed infants |
title_sort | differences in gut microbial fructoselysine degradation activity between breast-fed and formula-fed infants |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749803/ https://www.ncbi.nlm.nih.gov/pubmed/36442156 http://dx.doi.org/10.1093/femsec/fiac145 |
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