Cystatin B deficiency results in sustained histone H3 tail cleavage in postnatal mouse brain mediated by increased chromatin-associated cathepsin L activity

Cystatin B (CSTB) is a cysteine cathepsin inhibitor whose biallelic loss-of-function mutations in human result in defects in brain development and in neurodegeneration. The physiological function of CSTB is largely unknown, and the mechanisms underlying the human brain diseases remain poorly underst...

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Detalles Bibliográficos
Autores principales: Daura, Eduard, Tegelberg, Saara, Hakala, Paula, Lehesjoki, Anna-Elina, Joensuu, Tarja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749902/
https://www.ncbi.nlm.nih.gov/pubmed/36533126
http://dx.doi.org/10.3389/fnmol.2022.1069122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749902/
https://www.ncbi.nlm.nih.gov/pubmed/36533126
http://dx.doi.org/10.3389/fnmol.2022.1069122

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