Synthesis and structure–activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine

The brevicidine and laterocidine family of lipopeptide antibiotics exhibit strong activity against multidrug-resistant Gram-negative bacteria, while showing low propensity to induce resistance. Both peptides feature a branched lipid tail on the N-terminal residue, which for brevicidine is chiral. He...

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Detalles Bibliográficos
Autores principales: Ballantine, Ross D., Al Ayed, Karol, Bann, Samantha J., Hoekstra, Michael, Martin, Nathaniel I., Cochrane, Stephen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749936/
https://www.ncbi.nlm.nih.gov/pubmed/36545437
http://dx.doi.org/10.1039/d2md00281g

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