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Joint Analysis of Phenotypic and Genomic Diversity Sheds Light on the Evolution of Xenobiotic Metabolism in Humans

Variation in genes involved in the absorption, distribution, metabolism, and excretion of drugs (ADME) can influence individual response to a therapeutic treatment. The study of ADME genetic diversity in human populations has led to evolutionary hypotheses of adaptation to distinct chemical environm...

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Autores principales:	Mouterde, Médéric, Daali, Youssef, Rollason, Victoria, Čížková, Martina, Mulugeta, Anwar, Al Balushi, Khalid A, Fakis, Giannoulis, Constantinidis, Theodoros C, Al-Thihli, Khalid, Černá, Marie, Makonnen, Eyasu, Boukouvala, Sotiria, Al-Yahyaee, Said, Yimer, Getnet, Černý, Viktor, Desmeules, Jules, Poloni, Estella S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750130/ https://www.ncbi.nlm.nih.gov/pubmed/36445690 http://dx.doi.org/10.1093/gbe/evac167

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