Cargando…
Association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness
We examined whether genetic risk for mental illness is associated with known perinatal risk factors for offspring mental illness to determine whether gene-environmental correlation might account for the associations of perinatal factors with mental illness. Among 8983 women with 19,733 pregnancies,...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750139/ https://www.ncbi.nlm.nih.gov/pubmed/36516246 http://dx.doi.org/10.1126/sciadv.abn3740 |
_version_ | 1784850187397627904 |
---|---|
author | Ratanatharathorn, Andrew Chibnik, Lori B. Koenen, Karestan C. Weisskopf, Marc G. Roberts, Andrea L. |
author_facet | Ratanatharathorn, Andrew Chibnik, Lori B. Koenen, Karestan C. Weisskopf, Marc G. Roberts, Andrea L. |
author_sort | Ratanatharathorn, Andrew |
collection | PubMed |
description | We examined whether genetic risk for mental illness is associated with known perinatal risk factors for offspring mental illness to determine whether gene-environmental correlation might account for the associations of perinatal factors with mental illness. Among 8983 women with 19,733 pregnancies, we found that genetic risk for mental illness was associated with any smoking during pregnancy [attention-deficit hyperactivity disorder (ADHD) and overall genetic risk], breast-feeding for less than 1 month (ADHD, depression, and overall genetic risk), experience of intimate partner violence in the year before the birth (depression and overall genetic risk), and pregestational overweight or obesity (bipolar disorder). These results indicate that genetic risk may partly account for the association between perinatal conditions and mental illness in offspring. |
format | Online Article Text |
id | pubmed-9750139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-97501392022-12-21 Association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness Ratanatharathorn, Andrew Chibnik, Lori B. Koenen, Karestan C. Weisskopf, Marc G. Roberts, Andrea L. Sci Adv Social and Interdisciplinary Sciences We examined whether genetic risk for mental illness is associated with known perinatal risk factors for offspring mental illness to determine whether gene-environmental correlation might account for the associations of perinatal factors with mental illness. Among 8983 women with 19,733 pregnancies, we found that genetic risk for mental illness was associated with any smoking during pregnancy [attention-deficit hyperactivity disorder (ADHD) and overall genetic risk], breast-feeding for less than 1 month (ADHD, depression, and overall genetic risk), experience of intimate partner violence in the year before the birth (depression and overall genetic risk), and pregestational overweight or obesity (bipolar disorder). These results indicate that genetic risk may partly account for the association between perinatal conditions and mental illness in offspring. American Association for the Advancement of Science 2022-12-14 /pmc/articles/PMC9750139/ /pubmed/36516246 http://dx.doi.org/10.1126/sciadv.abn3740 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Social and Interdisciplinary Sciences Ratanatharathorn, Andrew Chibnik, Lori B. Koenen, Karestan C. Weisskopf, Marc G. Roberts, Andrea L. Association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness |
title | Association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness |
title_full | Association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness |
title_fullStr | Association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness |
title_full_unstemmed | Association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness |
title_short | Association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness |
title_sort | association of maternal polygenic risk scores for mental illness with perinatal risk factors for offspring mental illness |
topic | Social and Interdisciplinary Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750139/ https://www.ncbi.nlm.nih.gov/pubmed/36516246 http://dx.doi.org/10.1126/sciadv.abn3740 |
work_keys_str_mv | AT ratanatharathornandrew associationofmaternalpolygenicriskscoresformentalillnesswithperinatalriskfactorsforoffspringmentalillness AT chibniklorib associationofmaternalpolygenicriskscoresformentalillnesswithperinatalriskfactorsforoffspringmentalillness AT koenenkarestanc associationofmaternalpolygenicriskscoresformentalillnesswithperinatalriskfactorsforoffspringmentalillness AT weisskopfmarcg associationofmaternalpolygenicriskscoresformentalillnesswithperinatalriskfactorsforoffspringmentalillness AT robertsandreal associationofmaternalpolygenicriskscoresformentalillnesswithperinatalriskfactorsforoffspringmentalillness |