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PAX5 epigenetically orchestrates CD58 transcription and modulates blinatumomab response in acute lymphoblastic leukemia

Blinatumomab is an efficacious immunotherapeutic agent in B cell acute lymphoblastic leukemia (B-ALL). However, the pharmacogenomic basis of leukemia response to blinatumomab is unclear. Using genome-wide CRISPR, we comprehensively identified leukemia intrinsic factors of blinatumomab sensitivity, i...

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Detalles Bibliográficos
Autores principales:	Li, Yizhen, Moriyama, Takaya, Yoshimura, Satoshi, Zhao, Xujie, Li, Zhenhua, Yang, Xu, Paietta, Elisabeth, Litzow, Mark R., Konopleva, Marina, Yu, Jiyang, Inaba, Hiroto, Ribeiro, Raul C., Pui, Ching-Hon, Yang, Jun J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750140/ https://www.ncbi.nlm.nih.gov/pubmed/36516256 http://dx.doi.org/10.1126/sciadv.add6403

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