Hypoxia deactivates epigenetic feedbacks via enzyme-derived clicking proteolysis-targeting chimeras

Epigenetic mediation through bromodomain and extraterminal (BET) proteins have progressively translated protein imbalance into effective cancer treatment. Perturbation of druggable BET proteins through proteolysis-targeting chimeras (PROTACs) has recently contributed to the discovery of effective th...

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Detalles Bibliográficos
Autores principales: Do, Thang Cong, Lau, Jun Wei, Sun, Caixia, Liu, Songhan, Kha, Khoa Tuan, Lim, Seok Ting, Oon, Yu Yang, Kwan, Yuet Ping, Ma, Jia Jia, Mu, Yuguang, Liu, Xiaogang, Carney, Thomas James, Wang, Xiaomeng, Xing, Bengang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750146/
https://www.ncbi.nlm.nih.gov/pubmed/36516252
http://dx.doi.org/10.1126/sciadv.abq2216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750146/
https://www.ncbi.nlm.nih.gov/pubmed/36516252
http://dx.doi.org/10.1126/sciadv.abq2216

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