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Asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome
Cortical variations in cytoarchitecture form a sensory-fugal axis that shapes regional profiles of extrinsic connectivity and is thought to guide signal propagation and integration across the cortical hierarchy. While neuroimaging work has shown that this axis constrains local properties of the huma...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750154/ https://www.ncbi.nlm.nih.gov/pubmed/36516263 http://dx.doi.org/10.1126/sciadv.add2185 |
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author | Parkes, Linden Kim, Jason Z. Stiso, Jennifer Calkins, Monica E. Cieslak, Matthew Gur, Raquel E. Gur, Ruben C. Moore, Tyler M. Ouellet, Mathieu Roalf, David R. Shinohara, Russell T. Wolf, Daniel H. Satterthwaite, Theodore D. Bassett, Dani S. |
author_facet | Parkes, Linden Kim, Jason Z. Stiso, Jennifer Calkins, Monica E. Cieslak, Matthew Gur, Raquel E. Gur, Ruben C. Moore, Tyler M. Ouellet, Mathieu Roalf, David R. Shinohara, Russell T. Wolf, Daniel H. Satterthwaite, Theodore D. Bassett, Dani S. |
author_sort | Parkes, Linden |
collection | PubMed |
description | Cortical variations in cytoarchitecture form a sensory-fugal axis that shapes regional profiles of extrinsic connectivity and is thought to guide signal propagation and integration across the cortical hierarchy. While neuroimaging work has shown that this axis constrains local properties of the human connectome, it remains unclear whether it also shapes the asymmetric signaling that arises from higher-order topology. Here, we used network control theory to examine the amount of energy required to propagate dynamics across the sensory-fugal axis. Our results revealed an asymmetry in this energy, indicating that bottom-up transitions were easier to complete compared to top-down. Supporting analyses demonstrated that asymmetries were underpinned by a connectome topology that is wired to support efficient bottom-up signaling. Lastly, we found that asymmetries correlated with differences in communicability and intrinsic neuronal time scales and lessened throughout youth. Our results show that cortical variation in cytoarchitecture may guide the formation of macroscopic connectome topology. |
format | Online Article Text |
id | pubmed-9750154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-97501542022-12-21 Asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome Parkes, Linden Kim, Jason Z. Stiso, Jennifer Calkins, Monica E. Cieslak, Matthew Gur, Raquel E. Gur, Ruben C. Moore, Tyler M. Ouellet, Mathieu Roalf, David R. Shinohara, Russell T. Wolf, Daniel H. Satterthwaite, Theodore D. Bassett, Dani S. Sci Adv Neuroscience Cortical variations in cytoarchitecture form a sensory-fugal axis that shapes regional profiles of extrinsic connectivity and is thought to guide signal propagation and integration across the cortical hierarchy. While neuroimaging work has shown that this axis constrains local properties of the human connectome, it remains unclear whether it also shapes the asymmetric signaling that arises from higher-order topology. Here, we used network control theory to examine the amount of energy required to propagate dynamics across the sensory-fugal axis. Our results revealed an asymmetry in this energy, indicating that bottom-up transitions were easier to complete compared to top-down. Supporting analyses demonstrated that asymmetries were underpinned by a connectome topology that is wired to support efficient bottom-up signaling. Lastly, we found that asymmetries correlated with differences in communicability and intrinsic neuronal time scales and lessened throughout youth. Our results show that cortical variation in cytoarchitecture may guide the formation of macroscopic connectome topology. American Association for the Advancement of Science 2022-12-14 /pmc/articles/PMC9750154/ /pubmed/36516263 http://dx.doi.org/10.1126/sciadv.add2185 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Neuroscience Parkes, Linden Kim, Jason Z. Stiso, Jennifer Calkins, Monica E. Cieslak, Matthew Gur, Raquel E. Gur, Ruben C. Moore, Tyler M. Ouellet, Mathieu Roalf, David R. Shinohara, Russell T. Wolf, Daniel H. Satterthwaite, Theodore D. Bassett, Dani S. Asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome |
title | Asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome |
title_full | Asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome |
title_fullStr | Asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome |
title_full_unstemmed | Asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome |
title_short | Asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome |
title_sort | asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750154/ https://www.ncbi.nlm.nih.gov/pubmed/36516263 http://dx.doi.org/10.1126/sciadv.add2185 |
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