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New-Onset Diabetes Mellitus in Post-renal Transplant Patients on Tacrolimus and Mycophenolate: A Systematic Review

A frequent complication in kidney transplantation is post-transplant diabetes mellitus (PTDM). The primary goal of this study is to review the risk factors and preventive methods and compare the different available anti-diabetic medications for the management of PTDM. We searched databases like Pubm...

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Autores principales: Nandula, Savitri Aninditha, Boddepalli, Chinmayi Sree, Gutlapalli, Sai Dheeraj, Lavu, Vamsi Krishna, Abdelwahab Mohamed Abdelwahab, Rana, Huang, Ruimin, Potla, Shanthi, Bhalla, Sushen, AlQabandi, Yousif, Balani, Prachi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750229/
https://www.ncbi.nlm.nih.gov/pubmed/36532903
http://dx.doi.org/10.7759/cureus.31482
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author Nandula, Savitri Aninditha
Boddepalli, Chinmayi Sree
Gutlapalli, Sai Dheeraj
Lavu, Vamsi Krishna
Abdelwahab Mohamed Abdelwahab, Rana
Huang, Ruimin
Potla, Shanthi
Bhalla, Sushen
AlQabandi, Yousif
Balani, Prachi
author_facet Nandula, Savitri Aninditha
Boddepalli, Chinmayi Sree
Gutlapalli, Sai Dheeraj
Lavu, Vamsi Krishna
Abdelwahab Mohamed Abdelwahab, Rana
Huang, Ruimin
Potla, Shanthi
Bhalla, Sushen
AlQabandi, Yousif
Balani, Prachi
author_sort Nandula, Savitri Aninditha
collection PubMed
description A frequent complication in kidney transplantation is post-transplant diabetes mellitus (PTDM). The primary goal of this study is to review the risk factors and preventive methods and compare the different available anti-diabetic medications for the management of PTDM. We searched databases like Pubmed and Google Scholar for related articles using specific terms and phrases. Following a thorough investigation, we applied the inclusion and exclusion criteria and completed a quality assessment. Modifiable risk factors have a significant role in the development of PTDM. The combinations of immunosuppressive treatment tacrolimus (TAC), cyclosporine A (CYC), and everolimus (EVL), steroids increase the incidence of PTDM significantly. Insulin is the most effective treatment for PTDM in the early transplant period; however, oral anti-diabetic medications look promising. Further clinical trials are required to determine the optimum treatment method for reducing the occurrence of PTDM and treating the existing condition with novel anti-hyperglycemic medications.
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spelling pubmed-97502292022-12-15 New-Onset Diabetes Mellitus in Post-renal Transplant Patients on Tacrolimus and Mycophenolate: A Systematic Review Nandula, Savitri Aninditha Boddepalli, Chinmayi Sree Gutlapalli, Sai Dheeraj Lavu, Vamsi Krishna Abdelwahab Mohamed Abdelwahab, Rana Huang, Ruimin Potla, Shanthi Bhalla, Sushen AlQabandi, Yousif Balani, Prachi Cureus Internal Medicine A frequent complication in kidney transplantation is post-transplant diabetes mellitus (PTDM). The primary goal of this study is to review the risk factors and preventive methods and compare the different available anti-diabetic medications for the management of PTDM. We searched databases like Pubmed and Google Scholar for related articles using specific terms and phrases. Following a thorough investigation, we applied the inclusion and exclusion criteria and completed a quality assessment. Modifiable risk factors have a significant role in the development of PTDM. The combinations of immunosuppressive treatment tacrolimus (TAC), cyclosporine A (CYC), and everolimus (EVL), steroids increase the incidence of PTDM significantly. Insulin is the most effective treatment for PTDM in the early transplant period; however, oral anti-diabetic medications look promising. Further clinical trials are required to determine the optimum treatment method for reducing the occurrence of PTDM and treating the existing condition with novel anti-hyperglycemic medications. Cureus 2022-11-14 /pmc/articles/PMC9750229/ /pubmed/36532903 http://dx.doi.org/10.7759/cureus.31482 Text en Copyright © 2022, Nandula et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Nandula, Savitri Aninditha
Boddepalli, Chinmayi Sree
Gutlapalli, Sai Dheeraj
Lavu, Vamsi Krishna
Abdelwahab Mohamed Abdelwahab, Rana
Huang, Ruimin
Potla, Shanthi
Bhalla, Sushen
AlQabandi, Yousif
Balani, Prachi
New-Onset Diabetes Mellitus in Post-renal Transplant Patients on Tacrolimus and Mycophenolate: A Systematic Review
title New-Onset Diabetes Mellitus in Post-renal Transplant Patients on Tacrolimus and Mycophenolate: A Systematic Review
title_full New-Onset Diabetes Mellitus in Post-renal Transplant Patients on Tacrolimus and Mycophenolate: A Systematic Review
title_fullStr New-Onset Diabetes Mellitus in Post-renal Transplant Patients on Tacrolimus and Mycophenolate: A Systematic Review
title_full_unstemmed New-Onset Diabetes Mellitus in Post-renal Transplant Patients on Tacrolimus and Mycophenolate: A Systematic Review
title_short New-Onset Diabetes Mellitus in Post-renal Transplant Patients on Tacrolimus and Mycophenolate: A Systematic Review
title_sort new-onset diabetes mellitus in post-renal transplant patients on tacrolimus and mycophenolate: a systematic review
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750229/
https://www.ncbi.nlm.nih.gov/pubmed/36532903
http://dx.doi.org/10.7759/cureus.31482
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