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Overexpression of fatty acid desaturase 3 predicts poor prognosis in head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies worldwide, because its discovery time is in the late stage of the disease, so it is important to develop HNSCC biomarkers to achieve the purpose of early detection and treatment. Fatty acid desaturase 3 (FADS3), the...

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Autores principales: Su, Kuiwei, Wang, Ying, Gu, Hefeng, Ma, Lan, Xuan, Guihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750517/
https://www.ncbi.nlm.nih.gov/pubmed/36626435
http://dx.doi.org/10.1097/MD.0000000000032119
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author Su, Kuiwei
Wang, Ying
Gu, Hefeng
Ma, Lan
Xuan, Guihong
author_facet Su, Kuiwei
Wang, Ying
Gu, Hefeng
Ma, Lan
Xuan, Guihong
author_sort Su, Kuiwei
collection PubMed
description Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies worldwide, because its discovery time is in the late stage of the disease, so it is important to develop HNSCC biomarkers to achieve the purpose of early detection and treatment. Fatty acid desaturase 3 (FADS3), the third member of the FADS family, is involved in sphingolipid biosynthesis. Here, we for the first time investigated FADS3 expression in HNSCC, as well as its potential biological function, prognostic value and its impact on the immune system. In this study, we used bioinformatics for gene expression analysis, clinicopathological analysis, enrichment analysis, and immune infiltration analysis of The Cancer Genome Atlas (TCGA) datasets. Statistical analysis was done using R. Tumor IMmune Estimation Resource (TIMER) and CIBERSORT were used to analyze the effect of FADS3 on immune responses in HNSCC. Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan–Meier (KM) survival analysis, and the Human Protein Atlas (HPA) data were used to validate the results from bioinformatics analysis. Our findings indicate that FADS3 influences HNSCC prognosis. High expression of FADS3 is related to higher lymphatic metastasis, histologic grade, and lymphovascular invasion. Gene set enrichment analysis (GSEA) revealed that FADS3 is related to inhibition of amino acid metabolism. CIBERSORT analysis showed high FADS3 expression correlates with reduced levels of B cells. FADS3 is a marker of HNSCC, and high expression of FADS3 is associated with poor prognosis of HNSCC.
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spelling pubmed-97505172022-12-28 Overexpression of fatty acid desaturase 3 predicts poor prognosis in head and neck squamous cell carcinoma Su, Kuiwei Wang, Ying Gu, Hefeng Ma, Lan Xuan, Guihong Medicine (Baltimore) 5700 Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies worldwide, because its discovery time is in the late stage of the disease, so it is important to develop HNSCC biomarkers to achieve the purpose of early detection and treatment. Fatty acid desaturase 3 (FADS3), the third member of the FADS family, is involved in sphingolipid biosynthesis. Here, we for the first time investigated FADS3 expression in HNSCC, as well as its potential biological function, prognostic value and its impact on the immune system. In this study, we used bioinformatics for gene expression analysis, clinicopathological analysis, enrichment analysis, and immune infiltration analysis of The Cancer Genome Atlas (TCGA) datasets. Statistical analysis was done using R. Tumor IMmune Estimation Resource (TIMER) and CIBERSORT were used to analyze the effect of FADS3 on immune responses in HNSCC. Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan–Meier (KM) survival analysis, and the Human Protein Atlas (HPA) data were used to validate the results from bioinformatics analysis. Our findings indicate that FADS3 influences HNSCC prognosis. High expression of FADS3 is related to higher lymphatic metastasis, histologic grade, and lymphovascular invasion. Gene set enrichment analysis (GSEA) revealed that FADS3 is related to inhibition of amino acid metabolism. CIBERSORT analysis showed high FADS3 expression correlates with reduced levels of B cells. FADS3 is a marker of HNSCC, and high expression of FADS3 is associated with poor prognosis of HNSCC. Lippincott Williams & Wilkins 2022-12-09 /pmc/articles/PMC9750517/ /pubmed/36626435 http://dx.doi.org/10.1097/MD.0000000000032119 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 5700
Su, Kuiwei
Wang, Ying
Gu, Hefeng
Ma, Lan
Xuan, Guihong
Overexpression of fatty acid desaturase 3 predicts poor prognosis in head and neck squamous cell carcinoma
title Overexpression of fatty acid desaturase 3 predicts poor prognosis in head and neck squamous cell carcinoma
title_full Overexpression of fatty acid desaturase 3 predicts poor prognosis in head and neck squamous cell carcinoma
title_fullStr Overexpression of fatty acid desaturase 3 predicts poor prognosis in head and neck squamous cell carcinoma
title_full_unstemmed Overexpression of fatty acid desaturase 3 predicts poor prognosis in head and neck squamous cell carcinoma
title_short Overexpression of fatty acid desaturase 3 predicts poor prognosis in head and neck squamous cell carcinoma
title_sort overexpression of fatty acid desaturase 3 predicts poor prognosis in head and neck squamous cell carcinoma
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750517/
https://www.ncbi.nlm.nih.gov/pubmed/36626435
http://dx.doi.org/10.1097/MD.0000000000032119
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