Cargando…

How is gut microbiome of patients with familial adenomatous polyposis different from healthy people?

The gut microbiome has been increasingly suggested as an underlying cause of various human diseases. In this study, we hypothesized that the gut microbiomes of patients with familial adenomatous polyposis (FAP) are different from those of healthy people and attempted to identify the associations bet...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Jae Hyun, Kim, Yeon Ji, Oh, Gyu Man, Jung, Woohyuk, Park, Seun Ja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750518/
https://www.ncbi.nlm.nih.gov/pubmed/36626451
http://dx.doi.org/10.1097/MD.0000000000032194
_version_ 1784850273027489792
author Kim, Jae Hyun
Kim, Yeon Ji
Oh, Gyu Man
Jung, Woohyuk
Park, Seun Ja
author_facet Kim, Jae Hyun
Kim, Yeon Ji
Oh, Gyu Man
Jung, Woohyuk
Park, Seun Ja
author_sort Kim, Jae Hyun
collection PubMed
description The gut microbiome has been increasingly suggested as an underlying cause of various human diseases. In this study, we hypothesized that the gut microbiomes of patients with familial adenomatous polyposis (FAP) are different from those of healthy people and attempted to identify the associations between gut microbiome characteristics and FAP. We collected fecal samples from patients with FAP and healthy volunteers and evaluated the diversity, composition, and distribution of the gut microbiome between the 2 groups via 16S rRNA-based taxonomic profiling of the fecal samples. Fecal samples were collected from 10 patients with FAP (4 men and 6 women, mean age 39.2 ± 13.8 years) and 10 healthy volunteers (4 men and 6 women, mean age 40.9 ± 9.8 years). The microbial richness in patients with FAP was significantly lower than that in healthy people. Regarding microbial composition, the Firmicutes/Bacteroidetes ratio in patients with FAP was higher than that in healthy people, especially in those with a lower proportion of Bacteroidetes and a higher proportion of Proteobacteria. We also found 7 specific abundant strains in fecal samples of patients with FAP. Patients with FAP had different Firmicutes/Bacteroidetes ratios and Proteobacteria abundance compared to healthy people and showed the presence of specific bacteria. These findings suggest a promising role of the gut microbiome in patients with FAP, although further studies are needed.
format Online
Article
Text
id pubmed-9750518
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-97505182022-12-28 How is gut microbiome of patients with familial adenomatous polyposis different from healthy people? Kim, Jae Hyun Kim, Yeon Ji Oh, Gyu Man Jung, Woohyuk Park, Seun Ja Medicine (Baltimore) 4500 The gut microbiome has been increasingly suggested as an underlying cause of various human diseases. In this study, we hypothesized that the gut microbiomes of patients with familial adenomatous polyposis (FAP) are different from those of healthy people and attempted to identify the associations between gut microbiome characteristics and FAP. We collected fecal samples from patients with FAP and healthy volunteers and evaluated the diversity, composition, and distribution of the gut microbiome between the 2 groups via 16S rRNA-based taxonomic profiling of the fecal samples. Fecal samples were collected from 10 patients with FAP (4 men and 6 women, mean age 39.2 ± 13.8 years) and 10 healthy volunteers (4 men and 6 women, mean age 40.9 ± 9.8 years). The microbial richness in patients with FAP was significantly lower than that in healthy people. Regarding microbial composition, the Firmicutes/Bacteroidetes ratio in patients with FAP was higher than that in healthy people, especially in those with a lower proportion of Bacteroidetes and a higher proportion of Proteobacteria. We also found 7 specific abundant strains in fecal samples of patients with FAP. Patients with FAP had different Firmicutes/Bacteroidetes ratios and Proteobacteria abundance compared to healthy people and showed the presence of specific bacteria. These findings suggest a promising role of the gut microbiome in patients with FAP, although further studies are needed. Lippincott Williams & Wilkins 2022-12-09 /pmc/articles/PMC9750518/ /pubmed/36626451 http://dx.doi.org/10.1097/MD.0000000000032194 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 4500
Kim, Jae Hyun
Kim, Yeon Ji
Oh, Gyu Man
Jung, Woohyuk
Park, Seun Ja
How is gut microbiome of patients with familial adenomatous polyposis different from healthy people?
title How is gut microbiome of patients with familial adenomatous polyposis different from healthy people?
title_full How is gut microbiome of patients with familial adenomatous polyposis different from healthy people?
title_fullStr How is gut microbiome of patients with familial adenomatous polyposis different from healthy people?
title_full_unstemmed How is gut microbiome of patients with familial adenomatous polyposis different from healthy people?
title_short How is gut microbiome of patients with familial adenomatous polyposis different from healthy people?
title_sort how is gut microbiome of patients with familial adenomatous polyposis different from healthy people?
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750518/
https://www.ncbi.nlm.nih.gov/pubmed/36626451
http://dx.doi.org/10.1097/MD.0000000000032194
work_keys_str_mv AT kimjaehyun howisgutmicrobiomeofpatientswithfamilialadenomatouspolyposisdifferentfromhealthypeople
AT kimyeonji howisgutmicrobiomeofpatientswithfamilialadenomatouspolyposisdifferentfromhealthypeople
AT ohgyuman howisgutmicrobiomeofpatientswithfamilialadenomatouspolyposisdifferentfromhealthypeople
AT jungwoohyuk howisgutmicrobiomeofpatientswithfamilialadenomatouspolyposisdifferentfromhealthypeople
AT parkseunja howisgutmicrobiomeofpatientswithfamilialadenomatouspolyposisdifferentfromhealthypeople