Cargando…
A novel prognostic signature for lung adenocarcinoma based on cuproptosis-related lncRNAs: A Review
Lung adenocarcinoma (LUAD) is a highly heterogeneous disease with complex pathogenesis, high mortality, and poor prognosis. Cuproptosis is a new type of programmed cell death triggered by copper accumulation that may play an important role in cancer. LncRNAs are becoming valuable prognostic factors...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750635/ https://www.ncbi.nlm.nih.gov/pubmed/36626411 http://dx.doi.org/10.1097/MD.0000000000031924 |
_version_ | 1784850299543879680 |
---|---|
author | Di, Huang Zhao, Jiting Zhu, Xue Zhou, Xinpeng Hu, Yuanlong Wang, Mengjie Qiu, Zhanjun Zhang, Wei Chen, Xianhai |
author_facet | Di, Huang Zhao, Jiting Zhu, Xue Zhou, Xinpeng Hu, Yuanlong Wang, Mengjie Qiu, Zhanjun Zhang, Wei Chen, Xianhai |
author_sort | Di, Huang |
collection | PubMed |
description | Lung adenocarcinoma (LUAD) is a highly heterogeneous disease with complex pathogenesis, high mortality, and poor prognosis. Cuproptosis is a new type of programmed cell death triggered by copper accumulation that may play an important role in cancer. LncRNAs are becoming valuable prognostic factors in cancer patients. The effect of cuproptosis-related lncRNAs (CRlncRNAs) on LUAD has not been clarified. Based on the Cancer Genome Atlas database, CRlncRNAs were screened by co-expression analysis of cuproptosis- related genes and lncRNAs. Using CRlncRNAs, Cox and LASSO regression analyses constructed a risk prognostic model. The predictive efficacy of the model was assessed and validated using survival analysis, receiver operating characteristic curve, univariate and multifactor Cox regression analysis, and principal component analysis. A nomogram was constructed and calibration curves were applied to enhance the predictive efficacy of the model. Tumor Mutational Burden analysis and chemotherapeutic drug sensitivity prediction were performed to assess the clinical feasibility of the risk model. The novel prognostic signature consisted of 5 potentially high-risk CRlncRNAs, MAP3K20-AS1, CRIM1-DT, AC006213.3, AC008035.1, and NR2F2-AS1, and 5 potentially protective CRlncRNAs, AC090948.1, AL356481.1, AC011477.2, AL031600.2, and AC026355.2, which had accurate and robust predictive power for LUAD patients. Collectively, the novel prognostic signature constructed based on CRlncRNAs can effectively assess and predict the prognosis of patients and provide a new perspective for the diagnosis and treatment of LUAD. |
format | Online Article Text |
id | pubmed-9750635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-97506352022-12-28 A novel prognostic signature for lung adenocarcinoma based on cuproptosis-related lncRNAs: A Review Di, Huang Zhao, Jiting Zhu, Xue Zhou, Xinpeng Hu, Yuanlong Wang, Mengjie Qiu, Zhanjun Zhang, Wei Chen, Xianhai Medicine (Baltimore) 5700 Lung adenocarcinoma (LUAD) is a highly heterogeneous disease with complex pathogenesis, high mortality, and poor prognosis. Cuproptosis is a new type of programmed cell death triggered by copper accumulation that may play an important role in cancer. LncRNAs are becoming valuable prognostic factors in cancer patients. The effect of cuproptosis-related lncRNAs (CRlncRNAs) on LUAD has not been clarified. Based on the Cancer Genome Atlas database, CRlncRNAs were screened by co-expression analysis of cuproptosis- related genes and lncRNAs. Using CRlncRNAs, Cox and LASSO regression analyses constructed a risk prognostic model. The predictive efficacy of the model was assessed and validated using survival analysis, receiver operating characteristic curve, univariate and multifactor Cox regression analysis, and principal component analysis. A nomogram was constructed and calibration curves were applied to enhance the predictive efficacy of the model. Tumor Mutational Burden analysis and chemotherapeutic drug sensitivity prediction were performed to assess the clinical feasibility of the risk model. The novel prognostic signature consisted of 5 potentially high-risk CRlncRNAs, MAP3K20-AS1, CRIM1-DT, AC006213.3, AC008035.1, and NR2F2-AS1, and 5 potentially protective CRlncRNAs, AC090948.1, AL356481.1, AC011477.2, AL031600.2, and AC026355.2, which had accurate and robust predictive power for LUAD patients. Collectively, the novel prognostic signature constructed based on CRlncRNAs can effectively assess and predict the prognosis of patients and provide a new perspective for the diagnosis and treatment of LUAD. Lippincott Williams & Wilkins 2022-12-09 /pmc/articles/PMC9750635/ /pubmed/36626411 http://dx.doi.org/10.1097/MD.0000000000031924 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 5700 Di, Huang Zhao, Jiting Zhu, Xue Zhou, Xinpeng Hu, Yuanlong Wang, Mengjie Qiu, Zhanjun Zhang, Wei Chen, Xianhai A novel prognostic signature for lung adenocarcinoma based on cuproptosis-related lncRNAs: A Review |
title | A novel prognostic signature for lung adenocarcinoma based on cuproptosis-related lncRNAs: A Review |
title_full | A novel prognostic signature for lung adenocarcinoma based on cuproptosis-related lncRNAs: A Review |
title_fullStr | A novel prognostic signature for lung adenocarcinoma based on cuproptosis-related lncRNAs: A Review |
title_full_unstemmed | A novel prognostic signature for lung adenocarcinoma based on cuproptosis-related lncRNAs: A Review |
title_short | A novel prognostic signature for lung adenocarcinoma based on cuproptosis-related lncRNAs: A Review |
title_sort | novel prognostic signature for lung adenocarcinoma based on cuproptosis-related lncrnas: a review |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750635/ https://www.ncbi.nlm.nih.gov/pubmed/36626411 http://dx.doi.org/10.1097/MD.0000000000031924 |
work_keys_str_mv | AT dihuang anovelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT zhaojiting anovelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT zhuxue anovelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT zhouxinpeng anovelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT huyuanlong anovelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT wangmengjie anovelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT qiuzhanjun anovelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT zhangwei anovelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT chenxianhai anovelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT dihuang novelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT zhaojiting novelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT zhuxue novelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT zhouxinpeng novelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT huyuanlong novelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT wangmengjie novelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT qiuzhanjun novelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT zhangwei novelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview AT chenxianhai novelprognosticsignatureforlungadenocarcinomabasedoncuproptosisrelatedlncrnasareview |