HIV- 1 lentivirus tethering to the genome is associated with transcription factor binding sites found in genes that favour virus survival

Lentiviral vectors (LV) are attractive for permanent and effective gene therapy. However, integration into the host genome can cause insertional mutagenesis highlighting the importance of understanding of LV integration. Insertion site (IS) tethering is believed to involve cellular proteins such as...

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Detalles Bibliográficos
Autores principales: Suleman, Saqlain, Payne, Annette, Bowden, Johnathan, Haque, Sharmin Al, Zahn, Marco, Fawaz, Serena, Khalifa, Mohammad S., Jobling, Susan, Hay, David, Franco, Matteo, Fronza, Raffaele, Wang, Wei, Strobel-Freidekind, Olga, Deichmann, Annette, Takeuchi, Yasuhiro, Waddington, Simon N., Gil-Farina, Irene, Schmidt, Manfred, Themis, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750860/
https://www.ncbi.nlm.nih.gov/pubmed/35513551
http://dx.doi.org/10.1038/s41434-022-00335-4

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