MicroRNA-21 guide and passenger strand regulation of adenylosuccinate lyase-mediated purine metabolism promotes transition to an EGFR-TKI-tolerant persister state

In EGFR-mutant lung cancer, drug-tolerant persister cells (DTPCs) show prolonged survival when receiving EGFR tyrosine kinase inhibitor (TKI) treatments. They are a likely source of drug resistance, but little is known about how these cells tolerate drugs. Ribonucleic acids (RNAs) molecules control...

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Detalles Bibliográficos
Autores principales: Zhang, Wen Cai, Skiados, Nicholas, Aftab, Fareesa, Moreno, Cerena, Silva, Luis, Corbilla, Paul Joshua Anthony, Asara, John M., Hata, Aaron N., Slack, Frank J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750876/
https://www.ncbi.nlm.nih.gov/pubmed/35840668
http://dx.doi.org/10.1038/s41417-022-00504-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750876/
https://www.ncbi.nlm.nih.gov/pubmed/35840668
http://dx.doi.org/10.1038/s41417-022-00504-y

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