Ras drives malignancy through stem cell crosstalk with the microenvironment

Squamous cell carcinomas are triggered by marked elevation of RAS–MAPK signalling and progression from benign papilloma to invasive malignancy(1–4). At tumour–stromal interfaces, a subset of tumour-initiating progenitors, the cancer stem cells, obtain increased resistance to chemotherapy and immunot...

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Detalles Bibliográficos
Autores principales: Yuan, Shaopeng, Stewart, Katherine S., Yang, Yihao, Abdusselamoglu, Merve Deniz, Parigi, S. Martina, Feinberg, Tamar Y., Tumaneng, Karen, Yang, Hanseul, Levorse, John M., Polak, Lisa, Ng, David, Fuchs, Elaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750880/
https://www.ncbi.nlm.nih.gov/pubmed/36450983
http://dx.doi.org/10.1038/s41586-022-05475-6

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