Cargando…
Molecular Imaging of the GABAergic System in Parkinson’s Disease and Atypical Parkinsonisms
PURPOSE OF REVIEW: During recent years, there has been a growing interest in GABAergic alterations in parkinsonian disorders. This paper aims to review the latest literature published, focusing on in vivo neuroimaging, and to suggest potential future avenues of research in the field. RECENT FINDINGS...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750911/ https://www.ncbi.nlm.nih.gov/pubmed/36400877 http://dx.doi.org/10.1007/s11910-022-01245-z |
_version_ | 1784850361973997568 |
---|---|
author | Terkelsen, Miriam H. Hvingelby, Victor S. Pavese, Nicola |
author_facet | Terkelsen, Miriam H. Hvingelby, Victor S. Pavese, Nicola |
author_sort | Terkelsen, Miriam H. |
collection | PubMed |
description | PURPOSE OF REVIEW: During recent years, there has been a growing interest in GABAergic alterations in parkinsonian disorders. This paper aims to review the latest literature published, focusing on in vivo neuroimaging, and to suggest potential future avenues of research in the field. RECENT FINDINGS: A growing number of neuroimaging studies have focused on the association with different symptoms of Parkinson’s disease, thereby suggesting a GABAergic role in motor symptoms, gait disturbances, frontal cognition, somatic symptom disorder, and hallucinations. However, there are a number of conflicting results, and further investigations in larger, clinically well-defined cohorts are needed to elucidate possible correlations. In progressive supranuclear palsy, recent evidence suggests a decrease of GABA in the frontal lobe. SUMMARY: In this narrative review, we discuss the possible GABAergic role in the symptoms of PD and atypical parkinsonisms and outline possible research strategies for future neuroimaging of GABAergic changes in parkinsonian disorders. |
format | Online Article Text |
id | pubmed-9750911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-97509112022-12-16 Molecular Imaging of the GABAergic System in Parkinson’s Disease and Atypical Parkinsonisms Terkelsen, Miriam H. Hvingelby, Victor S. Pavese, Nicola Curr Neurol Neurosci Rep Neuroimaging (N. Pavese, Section Editor) PURPOSE OF REVIEW: During recent years, there has been a growing interest in GABAergic alterations in parkinsonian disorders. This paper aims to review the latest literature published, focusing on in vivo neuroimaging, and to suggest potential future avenues of research in the field. RECENT FINDINGS: A growing number of neuroimaging studies have focused on the association with different symptoms of Parkinson’s disease, thereby suggesting a GABAergic role in motor symptoms, gait disturbances, frontal cognition, somatic symptom disorder, and hallucinations. However, there are a number of conflicting results, and further investigations in larger, clinically well-defined cohorts are needed to elucidate possible correlations. In progressive supranuclear palsy, recent evidence suggests a decrease of GABA in the frontal lobe. SUMMARY: In this narrative review, we discuss the possible GABAergic role in the symptoms of PD and atypical parkinsonisms and outline possible research strategies for future neuroimaging of GABAergic changes in parkinsonian disorders. Springer US 2022-11-18 2022 /pmc/articles/PMC9750911/ /pubmed/36400877 http://dx.doi.org/10.1007/s11910-022-01245-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Neuroimaging (N. Pavese, Section Editor) Terkelsen, Miriam H. Hvingelby, Victor S. Pavese, Nicola Molecular Imaging of the GABAergic System in Parkinson’s Disease and Atypical Parkinsonisms |
title | Molecular Imaging of the GABAergic System in Parkinson’s Disease and Atypical Parkinsonisms |
title_full | Molecular Imaging of the GABAergic System in Parkinson’s Disease and Atypical Parkinsonisms |
title_fullStr | Molecular Imaging of the GABAergic System in Parkinson’s Disease and Atypical Parkinsonisms |
title_full_unstemmed | Molecular Imaging of the GABAergic System in Parkinson’s Disease and Atypical Parkinsonisms |
title_short | Molecular Imaging of the GABAergic System in Parkinson’s Disease and Atypical Parkinsonisms |
title_sort | molecular imaging of the gabaergic system in parkinson’s disease and atypical parkinsonisms |
topic | Neuroimaging (N. Pavese, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750911/ https://www.ncbi.nlm.nih.gov/pubmed/36400877 http://dx.doi.org/10.1007/s11910-022-01245-z |
work_keys_str_mv | AT terkelsenmiriamh molecularimagingofthegabaergicsysteminparkinsonsdiseaseandatypicalparkinsonisms AT hvingelbyvictors molecularimagingofthegabaergicsysteminparkinsonsdiseaseandatypicalparkinsonisms AT pavesenicola molecularimagingofthegabaergicsysteminparkinsonsdiseaseandatypicalparkinsonisms |