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Damaging missense variants in IGF1R implicate a role for IGF-1 resistance in the etiology of type 2 diabetes

Type 2 diabetes (T2D) is a heritable metabolic disorder. While population studies have identified hundreds of common genetic variants associated with T2D, the role of rare (frequency < 0.1%) protein-coding variation is less clear. We performed exome sequence analysis in 418,436 (n = 32,374 T2D ca...

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Detalles Bibliográficos
Autores principales:	Gardner, Eugene J., Kentistou, Katherine A., Stankovic, Stasa, Lockhart, Samuel, Wheeler, Eleanor, Day, Felix R., Kerrison, Nicola D., Wareham, Nicholas J., Langenberg, Claudia, O'Rahilly, Stephen, Ong, Ken K., Perry, John R.B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750938/ https://www.ncbi.nlm.nih.gov/pubmed/36530175 http://dx.doi.org/10.1016/j.xgen.2022.100208

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