An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration

Intronic polymorphic TOMM40 variants increasing TOMM40 mRNA expression are strongly correlated to late onset Alzheimer’s Disease. The gene product, hTomm40, encoded in the APOE gene cluster, is a core component of TOM, the translocase that imports nascent proteins across the mitochondrial outer memb...

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Detalles Bibliográficos
Autores principales: Periasamy, Agalya, Mitchell, Naomi, Zaytseva, Olga, Chahal, Arjun S., Zhao, Jiamin, Colman, Peter M., Quinn, Leonie M., Gulbis, Jacqueline M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750964/
https://www.ncbi.nlm.nih.gov/pubmed/36517509
http://dx.doi.org/10.1038/s41598-022-23280-z

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