Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone

Oncohistones represent compelling evidence for a causative role of epigenetic perturbations in cancer. Giant cell tumours of bone (GCTs) are characterised by a mutated histone H3.3 as the sole genetic driver present in bone-forming osteoprogenitor cells but absent from abnormally large bone-resorbin...

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Detalles Bibliográficos
Autores principales: Cottone, Lucia, Ligammari, Lorena, Lee, Hang-Mao, Knowles, Helen J., Henderson, Stephen, Bianco, Sara, Davies, Christopher, Strauss, Sandra, Amary, Fernanda, Leite, Ana Paula, Tirabosco, Roberto, Haendler, Kristian, Schultze, Joachim L., Herrero, Javier, O’Donnell, Paul, Grigoriadis, Agamemnon E., Salomoni, Paolo, Flanagan, Adrienne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750984/
https://www.ncbi.nlm.nih.gov/pubmed/36138226
http://dx.doi.org/10.1038/s41418-022-01031-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750984/
https://www.ncbi.nlm.nih.gov/pubmed/36138226
http://dx.doi.org/10.1038/s41418-022-01031-x

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